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:: Volume 11, Issue 1 (Spring 2021) ::
J Fasa Univ Med Sci 2021, 11(1): 3735-3740 Back to browse issues page
The Effects of Hydroalcoholic Extract of Thyme (Zataria multiflora Boiss.) on Mechanical Activity of Isolated Colon of Male Rat
Aminollah Bahaoddini1 , Fereshteh ِِDadfar 2, Mohhamad Ahmadipour1
1- Department of Biology, Shiraz University, Shiraz, Iran
2- Department of Biology, Payame Noor University, Tehran, Iran , fereshtehdadfar2003@yahoo.com
Abstract:   (452 Views)
Background & Objective: Thyme have been used as a medicinal plant traditionally for the treatment of digestive system disorders. In present study, the effect of hydroalcoholic extract of thyme on motility of isolated colon of male rat and its interaction with cholinergic, adrenergic and nitic oxide systems was performed.
 Materials & Methods: Ten adult male rats (180- 250 g) were kept in standard condition for one week. Then rats were anaesthetized by ethyl ether and their colon was isolated and divided in to 1 cm strips. The strips were held to a force transducer and inserted to organ bath contained Tyrode solution. The mechanical activity of strips was recorded by Power Lab system with administration of thyme extract (0.0175 mg/ml) and its solvent in experimental and sham groups, and after administration of acetylcholine, epinephrine and L-NAME drugs. Data were analyzed by SPSS software and independent-samples T-test.
 Results: The result showed a significant decrease in the mechanical activity of isolated colon after administration of the effective dose of thyme extract in base line and after of administration of acetylcholine.
There was no significant difference of mechanical activity of the strips at the presence of extract and its solvent after epinephrine and L-NAME administration.
Conclusion: It can be concluded that thyme extract caused colon relaxation via inhibition of cholinergic pathway and independent from adrenergic and nitric oxide systems.
Keywords: Zataria multiflora Boiss, Isolated colon, Mechanical Activity
Full-Text [PDF 234 kb]   (182 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2019/06/17 | Accepted: 2020/10/21 | Published: 2021/01/29
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Bahaoddini A, ِِDadfar F, Ahmadipour M. The Effects of Hydroalcoholic Extract of Thyme (Zataria multiflora Boiss.) on Mechanical Activity of Isolated Colon of Male Rat. J Fasa Univ Med Sci. 2021; 11 (1) :3735-3740
URL: http://jabs.fums.ac.ir/article-1-2046-en.html

Volume 11, Issue 1 (Spring 2021) Back to browse issues page
Journal of Fasa University of Medical Sciences
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