Journal of Advanced Biomedical Sciences
JABS
Sun, Mar 9, 2025
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Volume 14, Issue 3 (5-2024)
JABS 2024, 14(3): 200-209 |
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Ghaforyan H. Ultra-sensitive Two-dimensional Photonic Crystal Biosensor for Oral Cancerous Cell Detection. JABS 2024; 14 (3) :200-209
URL: http://jabs.fums.ac.ir/article-1-3073-en.html
URL: http://jabs.fums.ac.ir/article-1-3073-en.html
Department of Physics, Payame Noor University (PNU), Tehran, Iran , hghaforyan@pnu.ac.ir
Abstract: (470 Views)
Background & Objectives: Over the past two decades, biophotonic sensors based on two-dimensional (2D) photonic crystals (PhCs) have garnered significant attention in cancer diagnosis. This technology has become a crucial tool in early cancer detection and treatment response monitoring due to its ability to detect minute changes in biomarker concentrations and molecular interactions. The development of these sensors through advanced nano and microfabrication techniques has significantly improved diagnostic accuracy and speed, promising substantial enhancements in therapeutic outcomes for cancer patients.
Materials & Methods: A biosensor based on a 2D PhC was designed and simulated for the detection of oral cancer cells in a sample. The biosensor, structured with silicon rods in air using the Finite-Difference Time-Domain tool, utilizes five rods as an analyte for detecting normal and cancerous cells, thereby evaluating the sensor's performance.
Results: The variation in the transmission spectrum was studied to detect the presence of malignant cells in the test sample. The sensor's structural parameters were carefully adjusted to enhance its sensitivity, a crucial factor in the accurate detection of cancerous cells. Two critical parameters, Q-factor and sensitivity, were derived from the results. The sensor achieved a sensitivity of 1148 nm/RIU with a Q-factor of 193.
Conclusions: The designed biosensor demonstrates superior accuracy and sensitivity in identifying both malignant and normal cells in the test sample, making it suitable for real-time deployment in point-of-care applications.
Materials & Methods: A biosensor based on a 2D PhC was designed and simulated for the detection of oral cancer cells in a sample. The biosensor, structured with silicon rods in air using the Finite-Difference Time-Domain tool, utilizes five rods as an analyte for detecting normal and cancerous cells, thereby evaluating the sensor's performance.
Results: The variation in the transmission spectrum was studied to detect the presence of malignant cells in the test sample. The sensor's structural parameters were carefully adjusted to enhance its sensitivity, a crucial factor in the accurate detection of cancerous cells. Two critical parameters, Q-factor and sensitivity, were derived from the results. The sensor achieved a sensitivity of 1148 nm/RIU with a Q-factor of 193.
Conclusions: The designed biosensor demonstrates superior accuracy and sensitivity in identifying both malignant and normal cells in the test sample, making it suitable for real-time deployment in point-of-care applications.
Type of Study: Research |
Subject:
Biophysics
Received: 2024/05/26 | Accepted: 2024/07/31 | Published: 2024/11/2
Received: 2024/05/26 | Accepted: 2024/07/31 | Published: 2024/11/2
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)