[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Winter(In Press) ::
Back to the articles list Back to browse issues page
Investigating the Relationship between Serum Glucose and Inflammatory Markers in Diabetic Rats with Progressive Resistance Exercise
Maryam Vatandoust 1, Ali Zare2
1- Department of Exercise Physiology, Payame Noor University, Tehran, Iran , Maryam.Vatandost@pnu.ac.ir
2- Department of Exercise physiology, Faculty of Physical Education, Payame Noor University, Alborz, Iran
Abstract:   (82 Views)
Background & Objective: Diabetes Mellitus (DM) is a condition that is associated with an increase in inflammatory markers and studies show that resistance exercise with appropriate intensity can reduce inflammation generally. The aim of this study was to investigate the relationship of serum glucose with Interlekin18 (IL-18) and Tumor Necrosis Factor-alpha (TNF-α) in Diabetic rats with progressive resistance exercise.
Materials & Methods: In this experimental study, 32 Wistar male rats were distributed to sedentary control, trained control, sedentary diabetic, and trained diabetic groups of 8. Diabetes was induced by Streptozotocin (55 mcg/bw-i.v.). The resistance training protocol consisted of elevating upward from a ladder with weight, supporting an overload equivalent to 5% of body weight, during 6 weeks. The data obtained were analyzed by ANOVA and Tukey's posthoc multiple comparison tests, and a significance level of 5% was considered.
Results: According to results, serum concentrations of TNF-α and IL-18 decreased significantly in trained diabetic group compared to sedentary diabetic group after resistance training. While in the amount of TNF-α in the trained control group compared to the sedentary control group, a significant increase was observed, and in the amount of IL-18 in trained control group compared to the sedentary control group, a significant decrease was observed. But regarding the correlation between serum IL-18 concentration and glucose, only in sedentary control group, a significant correlation was observed.
Conclusions: Resistance training was able to reduce TNF-α and IL-18 inflammatory markers in trained diabetic rats and improve metabolic and immune aspects in diabetes mellitus.
Keywords: Resistance Training, Tumor Necrosis Factor-alpha, Interleukin-18, Diabetes Mellitus
Type of Study: Research | Subject: Physiology
Received: 2021/05/6 | Accepted: 2021/09/7
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Back to the articles list Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4343