Volume 4, Issue 2 (9-2014)                   JABS 2014, 4(2): 250-257 | Back to browse issues page

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heydari Y, hosseini S, keshavarz M, mozafar A, meshkibaf M, takhshid M. Evaluating the Effect of Vitamins E and C on Sexual Cell Lineages in Adult Male Rats under Oxidative Stress Induced by Endosulfan Consumption. JABS 2014; 4 (2) :250-257
URL: http://jabs.fums.ac.ir/article-1-242-en.html
Evaluating the Effect of Vitamins E and C on Sexual Cell Lineages in Adult Male Rats under Oxidative Stress Induced by Endosulfan Consumption
Yazdan Heydari1 , Shirzad Hosseini2 , Mojtaba Keshavarz * 3, Ahmad Mozafar4 , Mohammadhasaan Meshkibaf5 , Mohammadali Takhshid6
1- Department of Biology, Payamnoor University, Bavanat Branch, Fars, Iran.
2- Department of Anatomy, School of Medicine Tehran, University of Medical Sciences, Tehran, Iran.
3- Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran. , mojkeshavarz@yahoo.com
4- Young Researchers and Elite Club, Science and Research Branch, Islamic Azad University, Fars, Iran.
5- Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.
6- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (11100 Views)

Background & Objective: Endosulfan is one of the strong insecticides used in agriculture. This toxin is absorbed by inhalation and skin. Endosulfan has side effects such as infertility in men. This study surveys the effect of vitamins E and C on  preventing the harmful effects of Endosulfan on spermatogenesis in adult male rats.

Materials & Methods: Adult male rats (200-250 g) from Wistar rats were divided into five groups of 10 rats. Rats in the experimental groups one, two, three, and four received 10 mg/kg Endosulfan daily for 10 consecutive days via gavage. Moreover, during this period, rats of group two in addition to daily Endosulfan, received 20 mg / kg vitamin C daily, group three received 200mg / kg Vitamin E daily and group four received20mg / kg kg vitamin C plus 200mg / kg Vitamin E daily, by gavage. Control group received only routine food and water. At the end of this period, sexual cells were counted by light microscope on testis sections.  The results were analyzed by one-way ANOVA test and Duncan's test at p≤0.05.

Results: The results showed that vitamins E and C have inhibitory effect on the degenerative impact of Endosulfan on spermatogenesis.

Conclusion: The results of this study indicated that Endosulfan impairs spermatogenesis by increasing the oxidative stress. Vitamins E and C inhibit the degenerative effects of Endosulfan on spermatogenesis by reducing the oxidative stress.

Keywords: Endosulfan, Vitamins E and C, Rat, Spermatogenesis, Oxidative Stress
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Type of Study: Research | Subject: Physiology
Received: 2013/10/21 | Accepted: 2014/04/18 | Published: 2014/09/18
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