Journal of Advanced Biomedical Sciences

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behpoor N, moradi F, tadibi V. The Effect of Resistance Training Program with Citrulline-Malate on Blood Pressure, Nitric Oxide, and Vascular Endothelial Growth Factor in Postmenopausal Women with Prehypertension. JABS 2020; 10 (1) :1913-1923
URL: http://jabs.fums.ac.ir/article-1-2246-en.html

Background & Objective: Blood pressure generally increases after menopause. Training modalities with a supplement can influence blood pressure indices. The present study aims at investigating the effect of eight-week resistance training with citrulline-malate consumption on blood pressure, Nitric Oxide (NO), and Vascular Endothelial Growth Factor (VEGF) in postmenopausal women with prehypertension
Materials & Methods: The sample population is postmenopausal women with pre-hypertensive age ranging from 50 to 55 years old divided randomly into six groups, including “training + supplement”, “training + placebo”, “training”, “no training + supplement”, “supplement” and “placebo”. Resistance training was held 3 sessions per week in which the training intensity was 45% to 55% IRM. The supplement included citrulline-malate (8 g) an hour before each training session. Blood pressure, NO, and VEGE were measured using a barometer and kit before and after the training sessions. Two-way analysis of variance test and Tukey’s follow-up test were applied to analyze data.
Results: The findings demonstrated that training leads to a decrease in systolic and diastolic blood pressures while an increase in NO and VEGF. The results showed that an eight-week period of citrulline-malate supplementation has decreased systolic and diastolic blood pressure. Besides, it was revealed that eight weeks of citrulline-malate administration made NO and VEGF increase. Also, the results indicated that the "exercise + supplement" group has had the greatest effect on increasing NO and VEGF and reducing systolic and diastolic blood pressure. Moreover, the findings proved that resistance training with citrulline-malate made systolic and diastolic blood pressures in menopausal women with prehypertension reduce. These effects are accompanied by rising levels of NO and VEGF.
Conclusion: The findings revealed that the resistance training, which was applied in the present study, coupled with citrulline-malate supplementation, will improve blood pressure in postmenopausal women with hypertension.