Volume 8, Issue 2 (7-2018)                   JABS 2018, 8(2): 834-840 | Back to browse issues page

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Mostaghimi A, Torabzadeh Khorasani P, Ramezani M. The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice. JABS 2018; 8 (2) :834-840
URL: http://jabs.fums.ac.ir/article-1-1492-en.html
The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice
Arezo Mostaghimi1 , Parvin Torabzadeh Khorasani * 2, Mina Ramezani3
1- Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Alborz, Iran
2- Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Alborz, Iran , p.torabzadeh@gmail.com
3- Dept. of Biology, Islamic Azad University, Tehran, Iran
Abstract:   (4888 Views)

Background & Objectives: Retinoic acid is recognized as a regulator of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was done to investigate the effect of retinoic acid on the uterine tissue and estradiol and progesterone hormones in female adult BALB/c mice.
Material & Methods: In this study after determining the appropriate dose of retinoic acid, it was injected intraperitoneally (IP) for 30 days On 75 adult BALB/c mice with doses of 15 (Group I), 25 (Group II), and 35mg/kg.b.w (Group III), control group (non- injection) and sham (distilled water injection). ANOVA analysis and Duncan test were applied to compare the means with significance level (P˂0.05) and (P˂0.001).
Results: Uterine tissue studies indicated an increase in overall thickness of the uterus (endometrium, myometrium, perimeterum) (P<0.001), (P<0.05) increase number of closed glands, and decrease in open glands (P<0.001). The level of estradiol increased (P<0.05) and progesterone secretion decreased (P<0.05).
Conclusion: It can be concluded that retinoic acid has damaging effect on the uterus tissue and sexual hormones, and its use especially in female should be by awareness and under physician supervision.

Keywords: Retinoic acid, Uterus, Estradiol, Progesterone, Mice
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Type of Study: Research | Subject: Developmental Biology
Received: 2018/01/15 | Accepted: 2018/06/30 | Published: 2018/09/16
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