Background & Objective: There is plenty of fatty acids of omega-3 in Salmon Fish that affect brain development and function, therefore, this study aimed to investigate the effect of Salmon fish’s oil on learning avoidance in mature male rats. 

Materials & Methods: In this empirical study, we used 40 mature male rats that were enrolled into control, sham and experimental groups. The control group was not treated. The sham group received only 1 ml saline daily, 3 experimental groups of different types received 0.25, 0.5 and 0.75 ml/kg body weight respectively, for 28 days. For the evaluation of avoidance learning behavior, the shuttle box was used. The data was evaluated using ANOVA. 

Results: The results suggest that consumption of salmon oil significantly increases in minimum and maximum doses (P<0.01) and average doses (P<0.001) the process of avoidance learning.

Conclusion: Salmon oil can lead to increased learning. Therefore, further investigation can be used to treat learning disorders and memory.