Volume 6, Issue 1 (3-2016)                   JABS 2016, 6(1): 27-34 | Back to browse issues page

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Bakhshi Ganje M, Shekhha M H, Farashahi E, Mohammadzade M. Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity. JABS 2016; 6 (1) :27-34
URL: http://jabs.fums.ac.ir/article-1-762-en.html
Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity
Mohammad Bakhshi Ganje1 , Mohamad hassan Shekhha * 2, Ehsan Farashahi3 , Morteza Mohammadzade1
1- Genetics Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Yazd Clinical and Research Center for Infertility, Shahid Sadoughi University of Medical Science, Yazd, Iran , :she sheikhha@yahoo.com
3- Yazd Clinical and Research Center for Infertility, Shahid Sadoughi University of Medical Science, Yazd, Iran
Abstract:   (9580 Views)

Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with type 2 diabetes and obesity in Yazd, Iran.
Methods & Materials: Unrelated study subject controls (n=200) and type 2 diabetes cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of χ2 test.
Results: The rs16953002 A/G polymorphism of the FTO gene showed significant association with T2DM and obesity. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects.
Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and obesity risk in Yazd population.

Keywords: FTO gene, Type 2 diabetes, Obesity, Polymorphism
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Type of Study: Research | Subject: Medical Genetics
Received: 2015/05/31 | Accepted: 2015/12/20 | Published: 2016/06/17
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