Journal of Advanced Biomedical Sciences

Background & Objective: Adiponectin hormone is thought to be a component of obesity hormones and is a contributing factor in breast cancer, which increases the genetic variation of this effect. The aim of this study was to investigate the relationship between C11377G polymorphism of adiponectin gene and BMI with the risk of breast cancer.
Material & Methods: For this study, 128 patients with breast cancer and 128 healthy subjects were blood sampled. After the extraction of DNA by salting out method, the specimens were amplified with specific primers. After the PCR products were evaluated, some parts were utilized for determining the genotype of individuals by using the PCR-RFLP technique. At the end of the study, the results were analyzed by SPSS-23 software and Chi-square statistical analysis.
Results: The G allele frequency was 0.28 in the cancer group and 0.27 in the control group. There was no statistically significant association between the two groups for this polymorphism. By studying the relationship between this gene variation and other variables, it was found that C11377G polymorphism had a significant correlation with body mass index (p value=0.038, OR: 1.766, CI95%: 1.030-3.028) and smoking (p value=0.029. OR: 1.979, CI95%: 0.893-4.388).
Conclusion: The C11377G polymorphism of Adiponectin did not show a significant relationship and risk of breast cancer. However, body mass index showed a significant relationship with breast cancer. Also, people who carry this genetic change and high body mass index or smokers were prone to breast cancer.