Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
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2228-5105
2783-1523
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jalali
1393
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gregorian
2014
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بررسی اثرات جانبی داروی دفراسیروکس بر ساختار و عملکرد آنزیم کاتالاز کبدی گاو در شرایط In vitro
In vitro Studying of Deferasirox Side effects on the Structure and the Function of Bovine Liver Catalase
داروسازي و فارماکولوژِی
Pharmacology
پژوهشي
Research
<p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><font size="2"><b><span lang="FA" style="font-family: ">زمینه</span></b><span dir="ltr"></span><span dir="ltr"></span></font><b><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span></b><font size="2"><b><span lang="FA" style="font-family: ">و هدف</span></b><span lang="AR-SA" style="font-family: ">: امروزه کلاتورهای خوراکی از جمله داروی دفراسیروکس
برای درمان بار اضافی آهن ناشی از انتقال خون مورد استفاده قرار میگیرد. با توجه به
نقش حائز اهمیت کبد در سم زدایی و متابولیزه کردن داروها و اهمیت کاتالاز به عنوان
آنزیم کلیدی در سم زدایی بدن، در این مطالعه به بررسی اثر داروی دفراسیروکس به عنوان
عامل کلاته کنندهی آهن بر روی ساختار و سینتیک آنزیم کاتالاز کبد گاوی پرداخته شده
است</span><span lang="FA" style="font-family: ">.</span></font></p><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><font size="2"><b><span lang="FA" style="font-family: ">مواد</span></b><span dir="ltr"></span><span dir="ltr"></span></font><b><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span></b><font size="2"><b><span lang="FA" style="font-family: ">و</span></b><span dir="ltr"></span><span dir="ltr"></span></font><b><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span></b><font size="2"><b><span lang="FA" style="font-family: ">روشها:</span></b><span dir="ltr"></span><span dir="ltr"></span></font><b><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span></b><font size="2"><span lang="FA" style="font-family: ">دراین</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">مطالعهی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">تجربی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">تغییرات</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">فعالیت</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">آنزیم</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">در</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">حضور</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">و</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">عدم</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">حضور</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">غلظتهای</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">مختلف</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">داروی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">دفراسیروکس</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">با</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">استفاده</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">از</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">دستگاه</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">اسپکتوفوتومتر (مرئی- ماوراء
بنفش) اندازهگیری</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">شد. همچنین</span><span lang="AR-SA" style="font-family: "> </span><span lang="AR-SA" style="font-family: ">تغییر</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">در</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">ساختمان</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">سه</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">بعدی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">و</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">عملکردی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">آنزیم</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">با</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">استفاده</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">از</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">تغییرات</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">در</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">نشر</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">ذاتی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="AR-SA" style="font-family: ">آنزیم</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="AR-SA" style="font-size: 8pt mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">با</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">مطالعات</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">طیف</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">سنجی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">فلوئورسانس</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">بررسی</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">گردید.</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><span lang="FA" style="font-family: "><font size="2">دادهها
در نرم افزار </font></span><font face="Times New Roman"><span style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr">Excel</span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="font-family: "><span dir="rtl"></span><span dir="rtl"></span><font size="2">
تجزیه و تحلیل شدند.</font></span></p><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><font size="2"><b><span lang="FA" style="font-family: ">نتایج:</span></b><span dir="ltr"></span><span dir="ltr"></span></font><b><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span></b><font size="2"><span lang="FA" style="font-family: ">نتایج
مطالعات سینتیکی آنزیم نشان میدهد که</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><span lang="FA" style="font-family: "><font size="2">غلظتهای افزایشی دارو منجر به کاهش فعالیت آنزیم و در
نتیجه مهار واکنش آنزیمی کاتالاز گردید. همچنین در حضور دارو، شدت نشر ذاتی آنزیم
کاهش یافته و در محیط سه بعدی اطراف کروموفورهای آنزیم تغییرات فاحشی رخ داد. داروی
دفراسیروکس دارای 2 جایگاه اتصال روی آنزیم کاتالاز کبدی در دو دمای محیط و
فیزیولوژیک است<b>.</b></font></span></p><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><font size="2"><b><span lang="FA" style="font-family: ">نتیجهگیری:
</span></b><span lang="FA" style="font-family: ">نتایج مطالعات فوق نشان میدهد
که</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">داروی
دفراسیروکس به عنوان یک کلاتور، از طریق</span><span dir="ltr"></span><span dir="ltr"></span></font><span lang="FA" style="font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span><font face="Times New Roman"> </font></span><font size="2"><span lang="FA" style="font-family: ">اتصال به آهن موجود در جایگاه فعال آنزیم
کاتالاز، موجب مهار فعالیت آنزیم شده <span style="color: black"><font face="B Nazanin">و امکان دارد از
این طریق منجر به نارسایی و عوارض جانبی درکبد شود. </font></span></span><b><span style="color: black font-size: 8pt mso-bidi-font-size: 10.0pt mso-bidi-language: FA" dir="ltr"><o:p /></span></b></font></p><font face="Times New Roman" size="3"></font><!--stripped-->
<p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal"><font size="2"><font face="Times New Roman"><b><i><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">Background </span></i></b><b><i><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA mso-bidi-font-family: Cambria">&</span></i></b><b><i><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA"> Objective:</span></i></b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA"> Oral
chelators such as deferasirox are used to treat iron overload caused by blood
transfusion. Considering the significant role of liver in detoxification and
drug metabolism as well as the importance of catalase as a key enzyme in
detoxification, this study was performed to evaluate the effect of deferasirox,
which is an iron chelator on the structure and the synthesis of the bovine
liver catalase.</span></font></font></p><p class="MsoNoSpacing" style="margin: 0cm 0cm 10pt text-align: justify"><font size="2"><font face="Times New Roman"><b><i><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">Materials &
Methods:</span></i></b><b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA"> </span></b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">In this experimental study, the alterations
in catalase activity were measured in the absence and the presence of different
concentrations of deferasirox by using spectrophotometer (UV-Visible).
Moreover, we used fluorescence spectroscopic methods for investigating the
changes in three dimensional structure of enzyme and its function based on the
changes in intrinsic emission. The data were analyzed by Excel software.<b><o:p /></b></span></font></font></p><font face="Times New Roman" size="3"></font><p class="MsoNoSpacing" style="margin: 0cm 0cm 10pt text-align: justify"><font size="2"><font face="Times New Roman"><b><i><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">Results:</span></i></b><b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA"> </span></b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">Analyzing
the synthesis of the enzyme showed that increased drug concentrations lead to
decrease in the enzyme activity and consequently inhibition of catalase
enzymatic reaction. In addition, fluorescence data represented the significant
decreasing in intrinsic emission of enzyme in the presence of drug, which
indicates that significant changes have been done at three dimensional
environments around the enzyme chromophores. Analyzing the fluorescence
quenching data at different room and physiologic temperatures was represented
two binding sites for deferasirox on liver catalase enzyme.</span></font></font></p><p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt text-align: justify"><font size="2"><font face="Times New Roman"><b><i><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">Conclusion:</span></i></b><b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA"> </span></b><span style="color: black mso-bidi-font-size: 20.0pt mso-bidi-language: FA">Above
results suggest that deferasirox, as a chelator drug, can bind to the catalase
active site then leading to functional changes of enzyme by inactivation of it,
which results in side effects of this drug in liver and liver failure.</span><span lang="FA" style="color: black font-family: " dir="rtl"><o:p /></span></font></font></p><font face="Times New Roman" size="3"> </font>
دفراسیروکس, کاتالاز, سینتیک, ساختار, فلوئورسانس
Deferasirox, Catalase, Kinetic, Structure, Fluorescence
258
267
http://jabs.fums.ac.ir/browse.php?a_code=A-10-426-1&slc_lang=fa&sid=1
Maryam
Moradi
مریم
مرادی
maryamm28@gmail.com
1382405741
10031947532846005608
No
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
گروه زیست شناسی سلولی و مولکولی، دانشکده علوم زیستی، دانشگاه خوارزمی، تهران، ایران.
Adeleh
Divsalar
عادله
دیوسالار
divsalar@khu.ac.ir
10031947532846005609
10031947532846005609
Yes
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
گروه زیست شناسی سلولی و مولکولی، دانشکده علوم زیستی، دانشگاه خوارزمی، تهران، ایران.
Maryam
Saidifar
مریم
سعیدی فر
m.saidifar@gmail.com
10031947532846005610
10031947532846005610
No
Nanotechnology Research Institute, Material and Energy Research Center, Karaj, Iran.
پژوهشگاه فناوری نانو و مواد پیشرفته مرکز تحقیقات مواد و انرژی، تهران، ایران.
Ali Akbar
Saboury
علی اکبر
صبوری
saboury@ut.ac.ir
10031947532846005611
10031947532846005611
No
Institute of Biochemistry and Biophysics‚ University of Tehran, Tehran, Iran.
مرکز تحقیقات بیوشیمی بیوفیزیک، دانشگاه تهران، تهران، ایران.
Mohammad
Tahmaseb
محمد
طهماسب
Tahmaseb@tmu.ac.ir
10031947532846005612
10031947532846005612
No
Kharazmi University of Tehran
گروه زیست شناسی سلولی و مولکولی، دانشکده علوم زیستی، دانشگاه خوارزمی، تهران، ایران.