Journal of Advanced Biomedical Sciences

en Association between Anti-Citrullinated Peptide Antibodies (ACPA) Levels and Disease Severity in Patients with Rheumatoid Arthritis روماتولوژي Rheumatology پژوهشي Research <div style="text-align: justify;">Background & Objectives: This case–control study was conducted to assess the diagnostic accuracy of serum anti-cyclic citrullinated peptide (anti-CCP) antibodies in rheumatoid arthritis (RA) and to determine their correlation with disease activity, as measured by the Disease Activity Score in 28 joints using C-reactive protein (DAS28-CRP). Materials & Methods: A total of 70 patients with RA (85.7% female; mean age = 55.7 ± 11.73 years) and 70 age- and sex-matched healthy controls were included. Serum anti-CCP levels were measured using an enzyme-linked immunosorbent assay (ELISA), and disease activity was evaluated based on DAS28-CRP scores. Pearson’s correlation coefficient was applied to assess the relationship between anti-CCP levels and RA disease activity. Results: <a name="_Hlk159062459">Anti-CCP exhibited a sensitivity of 61.4% and a specificity of 98.6% for the diagnosis of RA. The mean serum anti-CCP concentration was significantly elevated in RA patients (220.2 ± 27.5 IU/mL) compared with controls (1.57 ± 0.52 IU/mL; p < 0.001). However, no statistically significant correlation was observed between anti-CCP levels and disease activity as determined by DAS28-CRP (p = 0.4).</a> Conclusion: Anti-CCP is a highly specific serological biomarker for the diagnosis of RA but does not demonstrate a significant association with disease activity as measured by DAS28-CRP. Further large-scale, longitudinal investigations are warranted to elucidate its potential role in predicting long-term joint destruction and disease progression.  </div> Anti-CCP, Rheumatoid Arthritis, DAS28-CRP, Disease Activity, Case-Control Study 43 51 http://jabs.fums.ac.ir/browse.php?a_code=A-10-621-1&slc_lang=en&sid=1 Poopak Mohaghegh پوپک محقق mohaghp @yahoo .com 100319475328460030468 0009-0003-5964-3916 Yes Department of Internal Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Mohammad Sadegh Ghasempuor محمدصادق قاسم پور drjahromi@yahoo.com 100319475328460030469 0009-0004-3272-8589 No Department of Internal Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Azizallah Dehghan عزبزاله دهقان dehghanaz@gmail.com 100319475328460030470 100319475328460030470 No Department of Epidemiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه اپیدمیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران