Journal of Advanced Biomedical Sciences

en ارتباط بین مدت زمان خواب و دیس‌لیپیدمی: یافته‌های یک مطالعه کوهورت بزرگ در مناطق روستایی ایران Association Between Sleep Duration and Dyslipidemia: Insights from a Large-Scale Cohort Study in Rural Iran بهداشت عمومی General Health پژوهشي Research Background & Objectives: Sleep duration is increasingly recognized as a critical determinant of overall health, particularly in relation to cardiovascular risk. Dyslipidemia, a leading contributor to cardiovascular disease, has been linked inconsistently to sleep duration, especially among rural populations. Materials & Methods: This population-based cohort study utilized data from the Fasa Adults Cohort Study (2014–2021), comprising 10,118 adults aged 35 to 70 years from the rural districts of Sheshdeh and Qarabolagh, Fasa County, Iran. Participants were categorized based on self-reported sleep duration (<7 hours vs. ≥7 hours). Anthropometric measurements, blood pressure, and fasting lipid profiles were collected. Dyslipidemia was defined according to Adult Treatment Panel III (ATP III) criteria. Statistical analyses included chi-square tests, t-tests, and multivariable logistic regression. Results: Individuals with short sleep duration (<7 hours) exhibited significantly higher body mass index (BMI), waist circumference, and low-density lipoprotein cholesterol (LDL-C) levels, as well as lower high-density lipoprotein cholesterol (HDL-C) levels (all p-values < 0.001). Short sleep duration was significantly associated with increased odds of dyslipidemia (adjusted odds ratio [OR] = 1.119; 95% confidence interval [CI]: 1.024–1.223; p = 0.013) and low HDL-C (adjusted OR = 1.239; 95% CI: 1.140–1.347; p < 0.001). No significant associations were observed with total cholesterol, triglycerides, or LDL-C. Conclusion: Short sleep duration is significantly associated with dyslipidemia and adverse lipid profiles, particularly reduced HDL-C levels. These findings highlight the importance of sleep health in mitigating cardiovascular risk, especially in underserved rural populations. Promoting sufficient sleep may serve as a viable preventive strategy against metabolic disorders. Further longitudinal studies are warranted to clarify underlying causal mechanisms.   Sleep Duration, Dyslipidemia, Cohort Study, Cardiovascular Risk, Metabolic Health 191 202 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1116-4&slc_lang=en&sid=1 Zahra Rahpeyma زهرا راه پیما zahrarahpeyma79@gmail.com 100319475328460029663 0009-0005-3062-1320 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی فسا، فسا، ایران Susan Darroudi سوسن درودی darroudis921@gmail.com 100319475328460029664 100319475328460029664 No Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran مرکز تحقیقات جراحی عروق و اندوواسکولار، دانشگاه علوم پزشکی مشهد، مشهد، ایران Mohammad Ebrahim Astaneh محمد ابراهیم آستانه meastaneh@yahoo.com 100319475328460029665 100319475328460029665 No Department of Anatomical Sciences, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه علوم تشریحی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Narges Fereydouni نرگس فریدونی narges.fereydouni2020@gmail.com 100319475328460029666 100319475328460029666 Yes Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران