Journal of Advanced Biomedical Sciences

en بررسی تأثیر دیابت و فشار خون بر افسردگی در جوانان: بینش‌هایی از گروه فسا Exploring the Impact of Diabetes Mellitus and Hypertension on Depression in Youth: Insights from the Fasa Cohort پرستاري Nursery پژوهشي Research <div style="text-align: justify;">Background & Objectives: Depression frequently coexists with chronic conditions such as diabetes mellitus (DM) and hypertension (HTN), compounding health risks and complicating disease management. While this relationship is well-documented in adults, its dynamics among adolescents and young adults remain insufficiently explored, particularly in culturally diverse contexts. This study aimed to assess the prevalence and associations of major depressive disorder (MDD), DM, and HTN among individuals aged 15–34 years in Fasa, Iran. Materials & Methods: A cross-sectional analysis was conducted on 3,014 participants from both rural and urban areas of Fasa. Data on depression, DM, and HTN were collected using validated self-report questionnaires and clinical assessments. Statistical analyses included Chi-square tests and logistic regression models to evaluate associations, adjusting for age, gender, smoking status, and other potential confounders. Results: Depression and DM were more prevalent among males (30.2% and 2.1%, respectively) compared to females (20.4% and 1.2%), whereas HTN was more common among females (7.0%). Depression was significantly associated with HTN in both univariate (OR = 2.710) and multivariate (OR = 2.547) models. Age and smoking status emerged as significant predictors of depression. Although a potential association between depression and DM was identified in the univariate analysis, it did not remain statistically significant after adjustment. Conclusion: This study highlights a significant gender-specific association between depression and HTN among youth, emphasizing the necessity for integrated, age-specific, and gender-sensitive mental and physical health interventions. No robust association was found between depression and DM.</div> Depression, Diabetes Mellitus, Hypertension, Youth, Sociodemographic Factors 179 190 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1116-3&slc_lang=en&sid=1 Zahra Keshavarz زهرا کشاورز keshavarzzahra1377@gmail.com 100319475328460029658 100319475328460029658 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی فسا، فسا، ایران Mohammad Ebrahim Astaneh محمدابراهیم آستانه meastaneh@yahoo.com 100319475328460029659 100319475328460029659 No Department of Anatomical Sciences, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه علوم تشریحی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Susan Darroudi سوسن درودی darroudis921@gmail.com 100319475328460029660 100319475328460029660 No Vascular and endovascular surgery research center, Mashhad University of Medical Sciences, Mashhad, Iran مرکز تحقیقات جراحی عروق و اندوواسکولار، دانشگاه علوم پزشکی مشهد، مشهد، ایران Amir Reza Khodaman امیررضا خدامان Amirrezakhodaman@gmail.com 100319475328460029661 100319475328460029661 No Department of psychiatry, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه روانپزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Narges Fereydouni نرگس فریدونی narges.fereydouni2020@gmail.com 100319475328460029662 100319475328460029662 Yes Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه مهندسی بافت، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران