Journal of Advanced Biomedical Sciences

en درمان هدفمند با نانوذرات طلا متصل به بتائین موجب کاهش التهاب و تنظیم ایمنی در گرمازدگی می شود Targeted Nanoparticle Therapy with Betaine-Conjugated Gold Nanoparticles Reduces Inflammation and Makes Immunomodulation in Heatstroke in Mice ايمونولوژي Immunology پژوهشي Research <div style="text-align: justify;">Background & Objectives: This study investigates the potential of betaine-conjugated gold nanoparticles (GNPs) as a treatment for inflammation caused by heatstroke. Heatstroke is characterized by elevated body temperature and severe inflammation, which can lead to organ dysfunction. Traditional treatments, such as cooling and supportive care, often fail to prevent long-term damage. GNPs serve as targeted carriers for delivering bioactive agents like betaine to inflamed tissues. The study used a murine model of heatstroke to assess the effects of GNPs, betaine, and their combination on inflammation markers and cellular stress. Materials & Methods: Mice were divided into groups receiving different treatments, and outcomes such as cytokine levels (TNF-α, IL-6, IL-10), heat shock protein (HSP70) expression, and splenocyte proliferation were measured. Results: The results demonstrated that the combination of GNPs and betaine notably decreased the amounts of pro-inflammatory cytokines (TNF-α and IL-6) while increasing the levels of the anti-inflammatory cytokine IL-10. The therapy also diminished HSP70 expression, which indicates lowered cellular stress in the GNP-betaine group. Additionally, treatment with GNP-betaine significantly promoted lymphocyte proliferation, indicating an enhancement in immune function under heatstroke conditions. Conclusion: This study emphasizes the promise of betaine-conjugated GNPs as an innovative therapeutic strategy for reducing inflammation and oxidative stress linked to heatstroke. The results illuminate the collaborative effects of nanotechnology and bioactive substances in addressing inflammatory pathways, presenting a hopeful avenue for managing heat-related inflammatory ailments.</div>   Heatstroke, Betaine, Gold Nanoparticle (GNP), Inflammation, Heat Shock Protein (HSP70) 319 330 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2435-2&slc_lang=en&sid=1 Alireza Loghmani علیرضا لقمانی Alirez.loghmani66@gmail.com 2471699685 100319475328460029335 Yes Department Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran گروه پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه لرستان، خرم آباد، ایران Mohammad Kamalpour کمال پور محمد kamalpour.m@lu.ac.ir 100319475328460029336 100319475328460029336 No Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran گروه علوم پایه، دانشکده دامپزشکی، دانشگاه لرستان، خرم آباد، ایران A Mohammad Amrollahi-Sharifabadi محمد امرللهی شریف آبادی amrollahi.m@lu.ac.ir 100319475328460029337 100319475328460029337 No Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran گروه علوم پایه، دانشکده دامپزشکی، دانشگاه لرستان، خرم آباد، ایران Mohammad Bahrami-Tapehbour محمد بهرامی تپه بور bahrami.mo@lu.ac.ir 100319475328460029338 0009-0001-8242-5701 No Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran گروه آناتومی و جنین شناسی، دانشکده دامپزشکی، دانشگاه لرستان، خرم آباد، ایران