en داروسازي و فارماکولوژِی Pharmacology گزارش مورد case report <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">is primarily managed through immunosuppression. Anti-thymocyte globulin (ATG), a polyclonal antibody derived from equine or lapine sources, is one such immunosuppressive treatment. While common side effects of ATG include allergic reactions, thrombocytopenia, headache, and myalgia, more severe but less frequent adverse effects encompass dyspnea and chest pain. The incidence and severity of liver function test abnormalities associated with ATG administration remain subjects of ongoing debate; however, most cases present with mild and transient enzyme elevations.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><u><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Case:</span></span></span></u></b>&nbsp;<span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">We present the case of a 13-year-old male child diagnosed with aplastic anemia (AA) who was admitted to the hematology clinic for ATG treatment. Three days after the initiation of ATG therapy, following the third dose, the patient developed severe hepatotoxicity. The patient experienced symptoms including chest pain, icterus, myalgia, and abdominal tenderness. Laboratory investigations revealed a significant elevation in liver enzymes and serum bilirubin levels. Upon discontinuation of ATG, the symptoms resolved within six days, accompanied by a marked reduction in liver enzymes and bilirubin levels. Subsequently, the patient received the fourth dose of ATG without adverse reactions.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><u><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Conclusion:</span></span></span></u></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Our patient developed frank symptomatic hepatitis, manifesting as icterus and right upper quadrant pain. Given the existing literature, this presentation does not appear to be common and warrants increased vigilance.</span></span></span></span></span></div> Aplastic anemia, Liver dysfunction, Anti-thymocyte globulin 244 249 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3374-1&slc_lang=en&sid=1 Mahdi Maleki Aghdam مهدی مالکی m.malekiaghdam@gmail.com 100319475328460029273 0009-0009-2387-3182 No Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران Negin Ebrahimpour نگین ابراهیم پور ebrahimpoornegin@gmail.com 100319475328460029274 0009-0000-1534-1236 No Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران Farid Ghazizadeh فرید قاضی زاده ghazizadeh.f@umsu.ac.ir 100319475328460029275 100319475328460029275 No Department of Pediatric Hematology, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran گروه هماتولوژی کودکان، بیمارستان مطهری، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران Zahra Ghelichkhan زهرا قلیچخان gkhan.z@umsu.ac.ir 100319475328460029276 100319475328460029276 Yes Experimental and Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran مرکز تحقیقات علوم تجربی و کاربردی داروسازی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران