Journal of Advanced Biomedical Sciences

en Risk Factors for COVID-19-Related Mortality among Hospitalized Patients in Southeastern Iran: A Case-Control Study اپيدميولوژي Epidemiology پژوهشي Research <div style="text-align: justify;">Background & Objectives: The COVID-19 pandemic has had a devastating global impact, with millions of cases and varying severity of illness. Southeastern Iran has been particularly hard hit, with a high number of patients requiring hospitalization. This study aimed to identify risk factors associated with mortality from COVID-19 among hospitalized patients in this region. Materials & Methods: A case-control study compared hospitalized COVID-19 patients who succumbed to the disease (confirmed by death certificates and positive PCR tests) with those who recovered, from February 27, 2020, to June 30, 2021. Researchers analyzed data using t-tests and chi-square tests to identify significant factors associated with mortality (p < 0.05). Variables significant at a less stringent level (p < 0.2) were then included in a backward logistic regression model to explore independent predictors of mortality. Results: This retrospective study examined data from 473 patients, of whom 158 were in the case group and 315 were in the control group. Among the case group, 80.4% were elderly, compared to 41% in the control group. A significantly higher proportion of patients in the case group (12.7%) experienced critical symptoms leading to ICU hospitalization, compared to the control group (7.3%). Multivariable regression analysis identified several factors significantly associated with increased mortality risk. These included ICU hospitalization (OR=5.27, CI: 3.09-8.98), advanced age (OR=4.06, CI: 2.43-6.80), hypertension (OR=4.44, CI: 1.52-12.93), cardiovascular diseases (OR=2.56, CI: 1.1-5.98), and critical symptoms (OR=2.74, CI: 1.92-8.04).  Diabetes, pregnancy, nationality, and gender did not statistically increase mortality risk (p-value ≥ 0.05). Conclusion: Advanced age, severe symptoms requiring ICU care, hypertension, and cardiovascular diseases are all critical mortality risk factors in hospitalized COVID-19 patients. </div> COVID-19, Mortality, Hospitalized patients, Risk factors, Iran 155 166 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3372-1&slc_lang=en&sid=1 Hekmatollah khoubfekr حکمت اله خوب فکر hekmatollah.1364@gmail.com 100319475328460028805 100319475328460028805 No Center of Health Vice-Chancellor of Iranshahr, University of Medical Sciences and Health Services, Iranshahr, Iran مرکز معاونت بهداشتی دانشگاه علوم پزشکی و خدمات بهداشتی درمانی ایرانشهر، ایرانشهر، ایران Motahareh Abdollahi مطهره عبداللهی motahareh.abdollahi@gmail.com 100319475328460028806 100319475328460028806 No Iranshahr Health Services, Iranshahr University of Medical Sciences, Iranshahr, Iran خدمات بهداشتی درمانی ایرانشهر، دانشگاه علوم پزشکی ایرانشهر، ایرانشهر، ایران Hamed Amiri حامد امیری alfred.amiri@gmail.com 100319475328460028807 100319475328460028807 No Iranshahr University of Medical Sciences and Health Services, Iranshahr, Iran دانشگاه علوم پزشکی و خدمات بهداشتی درمانی ایرانشهر، ایرانشهر، ایران Sadegh Amiri صادق امیری vaccin.irums@gmail.com 100319475328460028808 100319475328460028808 No Iranshahr University of Medical Sciences and Health Services, Iranshahr, Iran دانشگاه علوم پزشکی و خدمات بهداشتی درمانی ایرانشهر، ایرانشهر، ایران Saleh Babazadeh صالح بابازاده salehbaba@gmail.com 100319475328460028809 100319475328460028809 No Tulane University School of Public Health and Tropical Medicine,Stamford, New Orleans, LA, USA دانشکده بهداشت عمومی و پزشکی گرمسیری دانشگاه تولین، استمفورد، نیواورلئان، لس آنجلس، ایالات متحده آمریکا Vahid Rahmanian وحید رحمانیان vahid.rahmani1392@gmail.com 100319475328460028810 100319475328460028810 Yes Department of Public Health, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran گروه بهداشت عمومی، دانشکده علوم پزشکی تربت جام، تربت جام، ایران Mohammad Jokar محمد جوکار rakoj1375@gmail.com 100319475328460028811 100319475328460028811 No Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran دانشکده دامپزشکی، واحد کرج، دانشگاه آزاد اسلامی، کرج، ایران