en درمان مکمل با حنظل و شنبلیله در بیماران مبتلا به دیابت ، کارآزمایی بالینی دو سو کور داخلي Internal Medicine پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b><span style="color:#2f5496">Background & Objectives:</span></b> Diabetes is a known chronic disease affecting more than 400 million people and causing millions of deaths worldwide annually. The World Health Organization predicts that by 2030, diabetes will become the seventh leading cause of death. In the last decades, numerous chemotherapy approaches have been used. However, herbal remedies have accounted for more than 70 percent of the total administered antidiabetic treatments during the last decade. In this study, we aimed to develop a novel natural antidiabetic therapy with <em>Trigonella foenum-graecum</em> (<i>T. foenum-graecum</i>) L. and <em>Citrullus colocynthis</em> (<i>C.</i> <i>colocynthis</i>) (L.). Based on past studies, using <em>C. colocynthis</em> singly can cause diarrhea, abdominal pain, and heartburn, hence in order to reduce these complications, we applied this plant in combination with <i>T. foenum-graecum</i> based on the recommendations of Persian medicine references.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Materials & Methods:</span> We admitted 34 diabetics aged 30-65 years old to design a double-blind parallel randomized controlled clinical trial. We prepared therapeutic capsules containing a combination of 40 mg of <em>C. colocynthis</em> and 350 mg of <i>T. foenum-graecum </i>L. We divided participants into an interventional (n=17) and placebo (n=17) groups and measured fasting blood sugar (FBS) levels, lipid profile, and liver function tests initially. After two weeks, all participants returned for a visit, and FBS and blood sugar (BS) were measured. At the end (12^th week), all outcomes were measured and analyzed using an independent t-test and Chi-squared (&chi;²).</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Results:</span> The FBS levels decreased significantly in the intervention group compared to that of the control group (171.8&plusmn;54.9 versus 149.6&plusmn;46.4, p=0.024), but the improvements in the lipid profile and liver function were not statistically significant.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><span lang="EN" style="color:#2f5496">Conclusion:</span> This study unveiled that combination of <i>T. foenum-graecum </i>L. and <em>C. colocynthis </em>L. at safe levels significantly decreased the FBS levels among T2DM patients. Further studies are needed to provide more efficient antidiabetic effects with the low side effects.</span></span></div> <div style="text-align: justify;"></div> Diabetes, Trigonella foenum-graecum, Citrullus colocynthis, Herbal extracts, Treatment 104 114 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2122-1&slc_lang=en&sid=1 Babak Pezeshki بابک پزشکی babakpezeshki@yahoo.com 98 100319475328460028812 No Noncommunicable Diseases Research ‏Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران Seyed Mohammadreza Torabi سید محمد رضا ترابی aamrt7576@gmail.com 100319475328460028813 100319475328460028813 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی فسا، فسا، ایران Massih Sedigh Rahimabadi مسیح صدیق رحیم آبادی massih21@yahoo.com 100319475328460028814 100319475328460028814 No Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه طب ایرانی، دانشگاه علوم پزشکی فسا، فسا، ایران Hossein Pourmontaseri حسین پورمنتصری hossein.prm2000@gmail.com 100319475328460028815 100319475328460028815 No Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی فسا، فسا، ایران Foroogh Namjoyan فروغ نامجویان forooghnamjoyan@sums.ac.ir 100319475328460028816 100319475328460028816 No Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran مرکز تحقیقات طب سنتی و تاریخ طب، دانشگاه علوم پزشکی شیراز، شیراز، ایران Mohammad Hossein Dabbaghmanesh محمد حسین دباغ منش Dabbaghmanesh: dabbaghm@sums.ac.ir 100319475328460028817 100319475328460028817 No Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran مرکز تحقیقات غدد و متابولیسم، بیمارستان نمازی، دانشگاه علوم پزشکی شیراز، شیراز، ایران Elham Zarenezhad الهام زارع نژاد El.zarenezhad@gmail.com 100319475328460028818 100319475328460028818 No Noncommunicable Diseases Research ‏Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماریهای غیر واگیر، دانشگاه علوم پزشکی فسا، فسا، ایران Mehdi Sharafi مهدی شرفی mehdisharafi_2002@yahoo.com 100319475328460028819 100319475328460028819 No Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران Mahsa rostami chijan مهسا رستمی چایجان mahsa_59_2007@yahoo.com 100319475328460028820 100319475328460028820 Yes Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه طب ایرانی، دانشگاه علوم پزشکی فسا، فسا، ایران