en تطابق وضعیت HER2 بین بیوپسی سوزنی و نمونه‌های برداشته‌شده با جراحی سرطان پستان: مقاله مروری پاتولوژي Pathology مروری Review <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Background & Objective:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">HER2, a molecular biomarker, is routinely evaluated in breast cancer patients to guide therapeutic decisions. However, the concordance of HER2 status between core-needle biopsy (CNB) and surgical specimen (SS) samples is not always high, potentially affecting the accuracy of diagnosis and treatment. This study aims to review recent studies assessing the agreement of HER2 status between CNB and SS samples in breast cancer patients.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Materials & Methods:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> A literature search was conducted in PubMed, Scopus, and Google Scholar databases from January 2018 to August 2023 using the keywords: concordance, core needle biopsy, resection, HER2 status. Ten articles meeting the inclusion criteria were selected for this review.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Results:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">The results demonstrated variable concordance rates of HER2 status between CNB and SS samples, ranging from 83.3% to 99.5%. The primary factors influencing discordance were tumor heterogeneity, preoperative treatment, sampling error, and differing testing methods. Discordance was more prevalent in HER2-negative and HER2-low tumors compared to HER2-positive tumors.</span></span></span></span></span></span></div> <span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Conclusion:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">The concordance of HER2 status between CNB and SS samples is generally high but not perfect. Therefore, retesting HER2 status on SS samples is recommended to ensure optimal treatment decisions for breast cancer patients.</span></span></span></span></span></span><br> &nbsp; Core needle biopsy, Surgical specimen, Concordance, HER2 265 270 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3299-1&slc_lang=en&sid=1 Maryam Maghbool مریم مقبول maghbol.maryam@yahoo.com 2295494338 100319475328460028114 No Department of Pathology, Clinical Research Development Unit of Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran گروه آسیب شناسی، واحد توسعه تحقیقات بالینی بیمارستان ولیعصر، دانشگاه علوم پزشکی فسا، فسا، ایران Babak Samizadeh بابک سمیع زاده bsamizadeh8@gmail.com 2560090661 100319475328460028115 Yes Department of Pathology, Clinical Research Development Unit of Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran گروه آسیب شناسی، واحد توسعه تحقیقات بالینی بیمارستان ولیعصر، دانشگاه علوم پزشکی فسا، فسا، ایران