en ارتباط پلی مورفیسم های rs2273535 ژن AURKA و rs24330 ژن CDKN1B و افزایش خطر ابتلا به سرطان سینه ژنتيك عمومي Genetics پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background & Objective:</span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Breast cancer consists of a heterogeneous group of tumours with different prognosis and is the most common cause of cancer-related mortality among women. In this study, our goal was to evaluate the association of AURKA <span style="border:none windowtext 1.0pt; color:#333333; padding:0in">rs2273535 and </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">CDKN1B rs34330 polymorphisms</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> with risk of female breast cancer in southwest part of Iran.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials & Methods:</span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This case-control study was done on 50 women with breast cancer and 50 healthy women without any symptoms or family history of breast cancer as the case and control group, respectively. Restriction fragment length polymorphism (RFLP- PCR) technique was designed to determine the AURKA <span style="border:none windowtext 1.0pt; color:#333333; padding:0in">rs2273535 and </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">CDKN1B rs34330 gene polymorphisms. Afterwards, </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">statistical analysis was done by means of SPSS (version 17).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> In current research, our finding showed that rs2273535 T allele increased the susceptibility of breast cancer (OR:2.58, 95%CI:1.5-31.09, P=0.006). Moreover, T allele in dominant phase could raise the risk of the breast cancer (OR:3.01, 65%CI:1.31-6.92, P=0.009). However, the other polymorphism, </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">CDKN1B rs34330, revealed no associations with increased risk of breast cancer. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> These findings suggest that AURKA <span style="border:none windowtext 1.0pt; color:#333333; padding:0in">rs2273535</span> may influence individual&rsquo;s susceptibility to breast cancer. But we found no associations regarding </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">CDKN1B rs34330 polymorphism and this type of cancer.</span></span></span></span></span><br> &nbsp;</div> Breast cancer, AURKA, CDKN1B, rs2273535, rs34330, RFLP 422 430 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3157-1&slc_lang=en&sid=1 Atefeh Liravi عاطفه لیراوی Atefeh.liravi70@gmail.com 100319475328460026870 100319475328460026870 No Department of Genetic, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran گروه ژنتیک، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران seyed Massoud Houshmand سید مسعود هوشمند housh62@yahoo.com 100319475328460026871 100319475328460026871 Yes Department of Medical Genetic, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran گروه ژنتیک پزشکی، موسسه ملی مهندسی ژنتیک و بیوتکنولوژی، تهران، ایران Mojtaba Jafarnia مجتبی جعفرنیا jafarinia33@gmail.com 100319475328460026872 100319475328460026872 No Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran گروه زیست شناسی، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران Mohsen Forouzanfar محسن فروزانفر mforozanfar@yahoo.com 100319475328460026873 100319475328460026873 No Department of Genetic, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran گروه ژنتیک، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران