en روانپزشكي Psychiatry گزارش مورد case report <div style="text-align: justify;"><span style="font-size:13pt"><span style="text-justify:inter-ideograph"><span .applesystemuifont="" style="font-family:"><strong><i><span style="font-size:10.0pt"><span style="background:white">Background & Objective:</span></span></i></strong><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal"> Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) </span></span></span></span></span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">is a rare disease with a prevalence estimation of, 5 per, 100,000 individuals. Besides, it can highly be misdiagnosed with other psychiatric disorders.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:inter-ideograph"><span .applesystemuifont="" style="font-family:"><strong><i><span style="font-size:10.0pt"><span style="background:white">Case Presentation:</span></span></i></strong><strong> </strong><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">We report a case of CADASIL in</span></span><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal"> a 32-year-old </span></span></span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Asian female presenting with schizophrenia symptoms such as </span></span><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal">auditory hallucination </span></span></span></span></span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">،</span></span></span></span></span><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal">loosening of associations</span></span></span></span></span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">،</span></span></span></span></span><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal"> persecutory delusions</span></span></span></span></span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">،</span></span></span></span></span><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal"> referential delusions</span></span></span></span></span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">،</span></span></span></span></span><span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal"> decreased function, and complex hepatic hallucinations that the patient had said sometimes someone has intercourse with me since 2 years ago</span></span></span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">. After</span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> brain Magnetic Resonance Imaging</span></span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> (MRI) and gene checking, she showed up with NOTCH3 </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">gene, besides </span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Brain Magnetic resonance imaging</span></span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> confirmed the presence of CADASIL. Supportive treatments have been done and two years of following up showed a significant increase in patient life quality.</span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:inter-ideograph"><span .applesystemuifont="" style="font-family:"><strong><i><span style="font-size:10.0pt"><span style="background:white">Conclusion:</span></span></i></strong><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> This case report demonstrates the challenges of CADASIL diagnosis in a patient with schizophrenia symptoms. <span .sfui-semibold="" class="s1" style="font-family:"><span style="font-weight:bold"><span style="font-style:normal"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal">The diagnosis should be considered in patients with </span></span></span></span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">schizophrenia symptoms. </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Hence, there is a need for timely diagnosis and management of this disorder.</span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:inter-ideograph"><span .applesystemuifont="" style="font-family:"><b><span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></b></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:inter-ideograph"><span .applesystemuifont="" style="font-family:"><b><i><u><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:red">Keywords:</span></span></span></u></i></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">CADASIL, Brain</span></span><span .sfui-regular="" class="s2" style="font-family:"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Magnetic resonance imaging, </span></span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">NOTCH3 </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Gene, </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">schizophrenia</span></span></span></span></span></div> CADASIL, Brain Magnetic resonance imaging, NOTCH3 Gene, schizophrenia 235 239 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3114-1&slc_lang=en&sid=1 Farzaneh Modaresi فرزانه مدرسی dr.farzanehmodaresi2019@yahoo.com 100319475328460026512 100319475328460026512 No Department of Psychiatry, Fasa University of Medical Sciences, Fasa, Iran گروه روانپزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Mahboubeh Eslamzadeh محبوبه اسلام زاده Eslamzadehmh@mums.ac.ir 100319475328460026513 100319475328460026513 No Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran مرکز تحقیقات روانپزشکی و علوم رفتاری، دانشگاه علوم پزشکی مشهد، مشهد، ایران Aliasghar Karimi علی اصغر کریمی dr_aliasgharkarimi@yahoo.com 100319475328460026514 100319475328460026514 No Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری های غیرواگیردار، دانشگاه علوم پزشکی فسا، فسا، ایران Amir Ansari امیر انصاری dr.amiransari84@yahoo.com 100319475328460026515 100319475328460026515 Yes Department of Internal Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه پزشکی داخلی، دانشگاه علوم پزشکی فسا، فسا، ایران