Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
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2022
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Helianthus Annuus Seed Hydro-Alcoholic Extract Chemical Composition and Effects on Body Weight and Blood Parameters among Iraqi Patients Suffering from Type 2 Diabetes Mellitus
داروسازي و فارماکولوژِی
Pharmacology
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background & Objectives:</span></span></i></b><b> </b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The purpose of the present study was to calibrate and analyze the effects of <i>Helianthus annuus</i> (<i>H. annuus</i>) seeds extract on body weight and blood parameters of type-2 diabetic-mellitus (T2DM) patients. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Materials & Methods:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Three-hundred cases of T2DM patients were involved in this study including 180 males and 120 females and divided into two groups (each with 150 members). The herbal extract of <i>H. annuus</i> with a concentration of 500mg/kg was subjected to group1 (case population), but group 2 received normal diet for three months. Gas Chromatography mass spectrometry (GC/MS) was used to analyze <i>H. annuus</i> compounds. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Major <i>H. annuus</i> fraction included chlorogenic acid (CGA) being 40%. The extract conferred significant decreasing effects on hypertension but not body weight and body mass index (BMI) values. The extract receiving group vs control group regarding the mean blood factors respectively included fast blood glucose (FBS) (39.2% vs 3.22%, p<0.0001), cholesterol (6.9% vs 3.22%, p=0.0237), triglyceride (5.4% vs 2.30, p=0.0113), and increase in high-density lipoprotein (HDL) (22.3% vs 5.26%, p<0.001) and low-density lipoprotein (LDL) (1% vs 2.6%, p=0.0112). </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> <i>H. annuus</i> major compounds included CGA (40%) contributed to the control of the hypertension, lipid profile and the blood factors among T2DM patients compared to those patients who received normal diet. More detailed investigations by participation of higher number of patients are required in this regard. </span></span></span></span></span></div>
Helianthus-annuus, Diabetes Mellitus type 2, blood factors
223
228
http://jabs.fums.ac.ir/browse.php?a_code=A-10-1709-7&slc_lang=en&sid=1
Noor Al-Huda
Saeed
سعید
علی نورالهدی
noor.alhuda@gmail.com
100319475328460026105
100319475328460026105
No
Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq
گروه زیست شناسی، دانشکده علوم، دانشگاه مستنصریه، بغداد، عراق
Hussein Hamzah
Israa
اسرا
حسین حمزه
israa.s@gmail.com
100319475328460026106
100319475328460026106
No
Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq
گروه زیست شناسی، دانشکده علوم، دانشگاه مستنصریه، بغداد، عراق
Abdolmajid
Ghasemian
عبدالمجید
قاسمیان
majidghasemian86@gmail.com
100319475328460026107
100319475328460026107
Yes
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
مرکز تحقیقات بیماریهای غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران