en داروسازي و فارماکولوژِی Pharmacology پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background & Objectives:</span></span></i></b><b> </b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The purpose of the present study was to calibrate and analyze the effects of <i>Helianthus annuus</i> (<i>H. annuus</i>) seeds extract on body weight and blood parameters of type-2 diabetic-mellitus (T2DM) patients. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Materials & Methods:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Three-hundred cases of T2DM patients were involved in this study including 180 males and 120 females and divided into two groups (each with 150 members). The herbal extract of <i>H. annuus</i> with a concentration of 500mg/kg was subjected to group1 (case population), but group 2 received normal diet for three months. Gas Chromatography mass spectrometry (GC/MS) was used to analyze <i>H. annuus</i> compounds. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Major <i>H. annuus</i> fraction included chlorogenic acid (CGA) being 40%. The extract conferred significant decreasing effects on hypertension but not body weight and body mass index (BMI) values. The extract receiving group vs control group regarding the mean blood factors respectively included fast blood glucose (FBS) (39.2% vs 3.22%, p<0.0001), cholesterol (6.9% vs 3.22%, p=0.0237), triglyceride (5.4% vs 2.30, p=0.0113), and increase in high-density lipoprotein (HDL) (22.3% vs 5.26%, p<0.001) and low-density lipoprotein (LDL) (1% vs 2.6%, p=0.0112). &nbsp;</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> <i>H. annuus</i> major compounds included CGA (40%) contributed to the control of the hypertension, lipid profile and the blood factors among T2DM patients compared to those patients who received normal diet. More detailed investigations by participation of higher number of patients are required in this regard.&nbsp;&nbsp;</span></span></span></span></span></div> Helianthus-annuus, Diabetes Mellitus type 2, blood factors 223 228 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1709-7&slc_lang=en&sid=1 Noor Al-Huda Saeed سعید علی نورالهدی noor.alhuda@gmail.com 100319475328460026105 100319475328460026105 No Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq گروه زیست شناسی، دانشکده علوم، دانشگاه مستنصریه، بغداد، عراق Hussein Hamzah Israa اسرا حسین حمزه israa.s@gmail.com 100319475328460026106 100319475328460026106 No Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq گروه زیست شناسی، دانشکده علوم، دانشگاه مستنصریه، بغداد، عراق Abdolmajid Ghasemian عبدالمجید قاسمیان majidghasemian86@gmail.com 100319475328460026107 100319475328460026107 Yes Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران