en زنان و زايمان Gynecology & Obstetrics پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background & Objective:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Dietary antioxidants may play a protective role in the pathophysiology of gestational diabetes mellitus (GDM). The present study aimed to evaluate the effect of magnesium-vitamin E co-supplementation on glycemic control and pregnancy outcomes in women with GDM. </span></span><b><span dir="RTL" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Materials & Methods:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> This randomized clinical trial was conducted among GDM pregnant women at 24-28 weeks of gestation. The study did not include mothers who needed medication to control their blood glucose levels or had a history of DM. The subjects were randomly divided into two 30-member groups, one of which received magnesium (250 mg), and vitamin E (400 mg) daily, while the other was given a placebo. Blood samples were taken at the study baseline and six weeks after the intervention to quantify oxidative stress biomarkers, fasting plasma glucose (FPG), and fasting plasma insulin (FPI). Additionally, the effect of supplementation was assessed on neonatal outcomes.</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Data analysis was performed using SPSS 20 (SPSS, Chicago, IL)</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> A significant decrease was observed in the FPG and FPI of the supplementation group (p<0.05). However, FPI elevated by progressing pregnancy in the placebo group (<i>p</i>=1.99&times;10^-4). The homeostasis model assessment (HOMA) revealed that supplementation was associated with improved insulin sensitivity (<i>p</i>=3.38&times;10^-13). In addition, total antioxidant capacity increased to 5.66 &plusmn; 0.86% in the treatment group. Finally, no significant difference was found between the groups regarding neonatal outcomes.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The results represented that magnesium-vitamin E co-supplementation significantly reduced oxidative biomarkers and improved glycemic control in GDM. </span></span></span></span></span><br> &nbsp;</div> Magnesium, Vitamin E, Pregnancy,  Diabetes Mellitus, Oxidative stress 281 291 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2197-2&slc_lang=en&sid=1 Shima Hosseini شیما رحیمی dr.shimahosseini@gmail.com 100319475328460026541 100319475328460026541 No Clinical Research Development Unit (ShACRDU), Shahid Akbar Abadi Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran واحد توسعه تحقیقات بالینی (ShACRDU)، بیمارستان شهید اکبر آبادی، (IUMS)، تهران، ایران Maryam Rahimi مریم رحیمی me616us@yahoo.com 100319475328460026542 100319475328460026542 Yes Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran واحد توسعه تحقیقات بالینی (ShACRDU)، بیمارستان شهید اکبر آبادی، دانشگاه علوم پزشکی ایران (IUMS)، تهران، ایران Ali Farmoudeh علی فرموده farmoudeh.af@gmail.com 100319475328460026543 100319475328460026543 No Pharmaceutical Sciences Research Centre, Mazandaran University of Medical Sciences, Sari, Iran مرکز تحقیقات علوم دارویی، دانشگاه علوم پزشکی مازندران، ساری، ایران Amirali Fallah Amoli امیر علی فلاح آملی amirali.afa@gmail.com 100319475328460026544 100319475328460026544 No Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran واحد توسعه تحقیقات بالینی، بیمارستان امام حسین، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران Niloufar Beheshti Monfared نیلوفر بهشتی منفرد reza.soll@gmail.com 100319475328460026545 100319475328460026545 No Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran واحد توسعه تحقیقات بالینی (ShACRDU)، بیمارستان شهید اکبر آبادی، دانشگاه علوم پزشکی ایران (IUMS)، تهران، ایران