en فيزيولوژي Physiology مروری Review <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background & Objective:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Buprenorphine (BUP), a synthetic opioid, treats pain and opioid use syndrome. The potential of BUP to cause liver toxicity has not been fully evaluated. The present literature review was designed to investigate the impact of BUP treatment on liver function in patients without a previous history of liver diseases. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials & Methods:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> A literature review was implemented within databases of Scopus, PubMed, ISI, and Cochran until February 2022. Studies published in English were included in this study. Retrieved citations were screened and data were extracted by at least two independent reviewers.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Of the 1853 studies screened citations, 14 research reports were eligible. Overall, among the randomized controlled trial, four studies reported hepatotoxicity in patients who had a history of hepatitis C or hepatitis B seroconversion under BUP treatment.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> No strong evidence was found for hepatotoxicity of BUP in this study. Elevation in the liver enzyme levels in some patients may be related to other factors such as infectious diseases, illicit drugs, alcohol consumption, environmental pollutants, and chronic diseases. More experimental and clinical studies should be conducted to address this question.</span></span></span></span></span></span></span><br> &nbsp;</div> Buprenorphine, Liver, Toxicity, Hepatitis 250 263 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3050-1&slc_lang=en&sid=1 Maryam Rezaei مریم رضائی dr.rezaei.maryam@gmail.com 100319475328460026523 100319475328460026523 No Department of Endocrinology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran گروه غدد، دانشکده پزشکی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران Shahnaz Yousefizadeh شهناز یوسفی زاده sh.yousefizadeh@ilam.ac.ir 100319475328460026524 100319475328460026524 Yes Department of Laboratory and Clinical Sciences, Faculty of Para-Veterinary, Ilam University, Ilam, Iran گروه علوم آزمایشگاهی و بالینی، دانشکده پیراپزشکی، دانشگاه ایلام، ایلام، ایران