Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1400
2
1
gregorian
2021
5
1
11
2
online
1
fulltext
en
ارتباط سطح بالای تستوسترون و فریتین با اضافه وزن در زنان مبتلا به PCOS
Association of High Levels of Testosterone and Ferritin with Overweight in Women with PCOS
غدد
Endocrinology
پژوهشي
Research
<div style="text-align: justify;"><strong><em>Background & Objective</em></strong><em>:</em> The present study was conducted to determine testosterone and ferritin levels in women with polycystic ovary syndrome (PCOS) and investigate its relationship with body mass index (BMI)<br>
<strong><em>Materials & Methods</em></strong><em>:</em> In this case-control study, 104 PCOS cases and 99 controls were included. The concentration of testosterone, ferritin, lipid profile, insulin, glucose, and androgen was measured in fasting blood samples.<br>
<strong><em>Results</em></strong><em>:</em> Testosterone level was equal to 1.08 ± 0.50 and 0.85 ± 0.42 in the case and control groups, respectively (P< 0.001). Values of ferritin (123.45 ± 18.21ng/dl vs. 92.14 ± 17.74 ng/dl in control group, p< 0.001), insulin (11.41 ± 3.84 µU/ml vs. 7.02 ± 3.29 µU/ml in control group, p< 0.001), and insulin resistance (11.41 ± 3.84 vs.7.02 ± 3.29 in control group, p<sub>< </sub>0.001) were also measured. There was a significant relationship between serum concentration of testosterone and ferritin with BMI<span dir="RTL">) </span>p<0.001). The role of ferritin to predict PCOS was significant (ß:-1.1, P< 0.001).<br>
<strong><em>Conclusion</em></strong><em>:</em> According to the findings of the present study, the levels of testosterone and ferritin were increased in patients with PCOS. Although elevated testosterone levels are effective in PCOS, ferritin concentration is an important factor in predicting and exacerbating the disease.<br>
</div>
<span dir="RTL"></span><span dir="RTL"></span>
Testosterone, Ferritin, PCOS, Insulin, Insulin resistance
3886
3894
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2832-1&slc_lang=en&sid=1
Zeinab
Barartabar
زینب
برارتبار
zeinabbarartabar@gmail.com
0911898923
100319475328460026373
No
Students Research Committee, Hamadan University of Medical Sciences, Hamedan, Iran
کمیته تحقیقات دانشجویی ، دانشگاه علوم پزشکی همدان، همدان، ایران
Hiva
Danesh
هیوا
دانش
hivadanesh@yahoo.com
0938478065
100319475328460026374
No
Students Research Committee, Hamadan University of Medical Sciences, Hamedan, Iran
کمیته تحقیقات دانشجویی ، دانشگاه علوم پزشکی همدان، همدان، ایران
Sahar
Mazloomi
سحر
مظلومی
saharmazloomi1001@yahoo.com
0912841728
100319475328460026375
No
Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
گروه بیوشیمی بالینی ، دانشکده پزشکی ، دانشگاه علوم پزشکی همدان ، همدان ، ایران
Narges
Alizadeh
نرگس
علیزاده
nargesalizade4230@gmail.com
0918373378
100319475328460026376
No
Department of Obstetrics and Gynaecology, Shariati Hospital, Alborz University of Medical Sciences, Alborz, Iran
گروه زنان و زایمان، بیمارستان شریعتی، دانشگاه علوم پزشکی البرز، البرز، ایران
Shamim
Pilehvari
شمیم
پیله وری
sh.pilehvari@yahoo.com
100319475328460026377
100319475328460026377
Yes
Department of Obstetrics and Gynaecology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
گروه زنان و زایمان ، دانشکده پزشکی ، دانشگاه علوم پزشکی همدان ، همدان ، ایران