en اثرات تعدیل کننده ایمنی آنتی ژن های سوماتیک Fasciola hepatica و Teladorgasia circumcincta انگل شناسي Parasitology پژوهشي Research <div style="text-align: justify;"><strong><em>Background & Objective<span dir="RTL">:</span></em></strong> Infestation of humans with helminth parasites can reduce the severity of some auto-inflammatory symptoms in humans. This study was done to evaluate the impact of the somatic antigens extracted from&nbsp;<em>Fasciola hepatica</em>&nbsp;(as an indicator Trematode) ,and&nbsp;<em>Teladorgasia circumcincta</em>&nbsp;(as an indicator nematode) on the immune responses of NMRI mice challenged with sheep red blood cells (SRBCs). <span dir="RTL"></span><br> <strong><em>Materials & Methods:</em></strong> The mice in treatment groups were intraperitoneally immunized with 1&times;10⁹ SRBCs twice with 14 days intervals. Concurrent with the immunization, the mice received the extract of&nbsp;e<em>ach of the parasites</em>&nbsp;(50,100. And 150 &micro;g of protein) or placebo, throughout the study on a daily basis. The specific cellular immune responses and the anti-SRBC antibody titers were detected by footpad thickness and, microhemagglutination test, respectively. Splenocytes were also monitored for cytokine production, proliferation rate, and respiratory burst.<br> <strong><em>Results:</em></strong> The extracts of&nbsp;<em>F. hepatica</em>&nbsp;and&nbsp;<em>T. circumcincta</em>&nbsp;had an opposite effect on the change of the Anti-sRBC antibody level. The extract of&nbsp;<em>F. hepatica</em>&nbsp;caused a significant decrease in the antibody level whereas, extract&nbsp;<em>T. circumcin</em><em>cta</em>&nbsp;did not&nbsp;show any&nbsp;significant changes in the anti-SRBC antibody. Both extracts caused a significant decrease in the level of delayed-type hypersensitivity. However, the extract of&nbsp;<em>F. hepatica</em>&nbsp;caused a more profound reduction in the severity of delayed-type hypersensitivity. The level of IFN-&gamma; in the splenocytes of immunized mice receiving the <em>F. hepatica</em> showed a more pronounced decrease than the immunized mice receiving the extract of <em>T. circumcincta</em> extract. IL-10 levels were only increased in the immunized mice that received the extract of <em>F. hepatica</em>.<br> <strong><em>Conclusion:</em></strong> The extract of&nbsp;<em>F. hepatica</em>&nbsp;<a name="_Hlk63120063">may have</a> an immunosuppressive property, while the extract of&nbsp;<em>T. circumcincta&nbsp;</em>may have immunomodulatory properties.<br> &nbsp;</div> <strong><em>Keywords:</em></strong>&nbsp;<span dir="RTL"></span> Fasciola hepatica, Teladorgasia circumcincta, Somatic antigen, Immunoregulation 3913 3920 http://jabs.fums.ac.ir/browse.php?a_code=A-10-490-7&slc_lang=en&sid=1 Ali Moradian علی مرادیان alimoradiandvm@gmail.com 100319475328460026385 100319475328460026385 No Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia Iran گروه میکروب شناسی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران Seyyed Meysam Abtahi Froushani سید میثم ابطحی فروشانی meysamabtahi@hotmail.com 1141161435 100319475328460026386 Yes Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia Iran گروه میکروب شناسی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران Bijan Esmaeilnejad بیژن اسمعیل نژاد b_esmaeilnejad@yahoo.com 100319475328460026387 100319475328460026387 No Department of Pathobiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran گروه پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران