fa اثرات عناب بر بهبود یافته‌های بالینی و آزمایشگاهی بیماری ذخیره گلیکوژن نوع Ib، گزارش مورد و مرور متون گوارش Gastroenterology گزارش مورد case report <p dir="RTL"><strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">زمینه و هدف</span></span></span></span></strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">: بیماری ذخیره گلیکوژن نوع </span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">Ib</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">، یک بیماری متابولیک با اختلال متابولیسم کربوهیدرات است که بیماران درنتیجه تولید ناکافی گلوکز از گلیکوژن دچار اختلالات متابولیسمی شده و به علت نوتروپنی به عفونت</span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">&shy;</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">های راجعه مبتلا می</span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">&shy;</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">شوند. برای اولین بار در ایران و جهان بیماری که با مصرف داروی گیاهی بهبودی یافته است را معرفی می</span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">&shy;</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">نماییم.</span></span></span></span><br> <strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">مورد:</span></span></span></span></strong> <span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">دختر 5 ساله مبتلا به بیماری ذخیره گلیکوژن نوع </span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">Ib</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">، باسابقه تشنج شیرخوارگی درزمینه</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10pt;">ٔ</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;"> هیپوگلیسمی، هپاتومگالی، نوتروپنی، هیپرلیپیدمی و اسیدوز متابولیک است که به دلیل زخم&shy;های دهانی و عفونت&shy;های شدید در حملات نوتروپنی تحت درمان ماهانه با </span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">G-CSF</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;"> قرار &shy;داشت، با تجویز میوه عناب زخم&shy;های دهانی بهبود یافته و حملات عفونت و نوتروپنی بیمار از بین رفتند و بعد از شش ماه نیاز به تجویز </span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">G-CSF</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;"> پیدا نکرد.</span></span></span></span><br> <strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">نتیجه‌گیری</span></span></span></span></strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;">: استفاده از عناب می&shy;تواند موجب عدم رخداد نوتروپنی، عفونت و آفت دهانی در بیماری ذخیره گلیکوژن نوع </span></span></span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8pt;">Ib</span></span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10pt;"> گردد.</span></span></span></span><br> &nbsp;</p> <p><strong>Background & Objectives<em>:</em></strong> Glycogen storage disease type Ib is a metabolic disease of carbohydrate metabolism. Patients suffer from metabolic disorders as a result of insufficient production of glucose from glycogen, and recurrent infections due to neutropenia. For the first time in Iran and in the world, we introduce a patient who was improved with herbal medicine.<br> <strong>Case<em>:</em></strong> A 5-year-old girl with glycogen storage disease type Ib, with a history of infantile hypoglycemic seizures, hepatomegaly, neutropenia, hyperlipidemia and metabolic acidosis participated in this study. She was under monthly treatment with G-CSF due to neutropenia induced recurrent oral ulcers and severe infection. After using Jujube fruit, her oral lesions improved and the patient&rsquo;s infection attacks and neutropenia disappeared and there was no need for the administration of G-CSF after six months.<br> <strong>Conclusion:</strong> The use of jujube can lead to the improvement of neutropenia, infection and oral lesions in glycogen storage disease type Ib.<br> &nbsp;</p> عناب, بیماری ذخیره گلیکوژن نوع Ib, نوتروپنی, زخم‌های دهانی Jujube, glycogen storage disease type Ib, neutropenia, oral ulcers 291 296 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1115-3&slc_lang=fa&sid=1 shahsanam Geibi شاهصنم غیبی gheibi1345sh@gmail.com 100319475328460017799 100319475328460017799 No Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran مرکز تحقیقات چاقی مادر و کودک، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران hadi esamili govarchin galeh هادی اسمعیلی گورچین قلعه h.smaili,9@yahoo.com 100319475328460017800 100319475328460017800 Yes Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran مرکز تحقیقات چاقی مادر و کودک، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران bahman mansori motlagh بهمن منصوری مطلق b.mansori,8@gmail.com 100319475328460017801 100319475328460017801 No Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran مرکز تحقیقات چاقی مادر و کودک، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران