Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
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2228-5105
2783-1523
8
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8888
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en
jalali
1393
8
1
gregorian
2014
11
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online
1
fulltext
fa
بررسی اثر چند داروی ضد قارچی متداول
Effects of Several Common Antifungal Drugs (Clotrimazole, Miconazole, Fluconazole) alone and in Combination with Amphotericin B on Candida Species Isolated from Chronic Candidal Vulvovaginitis
قارچ شناسي
Mycology
پژوهشي
Research
<p style="direction: rtl"><font face="Times New Roman" size="3"> </font><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">زمینه
و هدف</span></b><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>: </span></b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">واژینیت
کاندیدیایی در اثر رشد بیش از حد گونههای کاندیدا به ویژه گونه آلبیکنس در دستگاه
تناسلی زنان بروز میکند</span><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>. </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">این
عفونت ممکن است به درمان مقاوم شود و گاهی هم به صورت مزمن درآید، همچنین گاهی
بیماران پس از درمان با عود دوباره عفونت مواجه میشوند.از طرفی کشف داروهای
ضدقارچی جدید توسط محققین و استفاده توام این داروها در قالب روشهای نوین علاقه
قارچشناسان را به استفاده از این تکنیکها برانگیخته است؛ لذا با استناد به روش</span><span dir="ltr"></span><span dir="ltr"></span><span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">های
فوق، در این مطالعه اثر داروهای متداول ضدقارچی، به تنهایی و در همبست با
آمفوتریسینب</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr"></span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، بر روی گونههای
کاندیدا آلبیکنس جدا شده از واژینیت کاندیدیایی مزمن ارزیابی شد</span><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></p><p class="MsoNormal" style="margin: 0cm -0.05pt 0pt 0cm text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">مواد
و روشها</span></b><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>: </span></b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">این
بررسی تجربی بر روی 19 استرین کاندیدا آلبیکنس جدا شده از واژینیت کاندیدیایی مزمن
انجام شد و اثر داروهای کلوتریمازول، مایکونازول و فلوکونازول، به تنهایی و در
همبست با آمفوترسینب، بر روی استرینهای کاندیدیایی به روش میکرودایلوشن در محیط
مایع ارزیابی شد</span><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></p><p class="MsoNormal" style="margin: 0cm -0.05pt 0pt 0cm text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نتایج</span></b><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>: </span></b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">میانگین</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">MIC </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">کلوتریمازول، مایکونازول، فلوکونازول و
آمفوتریسینب، بعد از 48 ساعت گرمخانهگذاری به ترتیب 05/7، 7/10،47 و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">6/0 </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">میکروگرم بر میلیلیتر به
دست آمد. در مرحله بعد آزولها در همبست با آمفوتریسینب بررسی شدند و دو همبست
فلوکونازول+آمفوتریسینب با 6/0</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">FIC= </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و
مایکونازول +آمفوتریسینب با</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">FIC=1 </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">از
همه بیشتر مورد توجه بودند. همچنین در بررسی اثر قارچ</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">کشی داروها، بیشترین اثر قارچ</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">کشی در مورد آمفوتریسین ب با 18/1</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">MFC= </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">دیده شد</span><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></p><p class="MsoNormal" style="margin: 0cm -0.05pt 0pt 0cm text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نتیجهگیری</span></b><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>: </span></b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">در
مطالعه ما، آمفوتریسینب با کمترین</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">MIC</span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">بیشترین اثر ضدقارچی را داشت اما بیشترین و کمترین
اثر همافزایی به ترتیب از همبستهای فلوکونازول + آمفوتریسینب</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و
مایکونازول+آمفوتریسینب، بدست آمد</span><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span><span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt"><o:p /></span></p><p><font face="Times New Roman" size="3"> </font></p>
<p><font face="Times New Roman" size="3"> </font><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Background&
Objective:</span></i></b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> Candidal vulvovaginitis
occurs in female genital by the over growth of candida especially candida
albicans. This infection may be resistant to therapy and occasionally becomes
chronic. In some patients, this form of infection is recurrent. Moreover,
discovering new antifungal drugs and the use of these drugs in new methods
encourage mycologists to use these techniques. Therefore, according to the
above methods, this research investigated effects of several common antifungal
drugs with the use of combination methods against candida species isolated from
chronic candidal vulvovaginitis.</span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal"><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Materials&
Methods:</span></i></b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> This study carried out
on 19 strains of candida albicans that were isolated from recurrent
vulvovaginitis. The effects of clotrimazole, miconazole, fluconazole were
assessed separately and in combination with amphotericin B on candida albicans
using micro dilution methods.</span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal"><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Results:</span></i></b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> The mean Minimum Inhibitory Concentration (MIC)
of clotrimazole, miconazole, fluconazole, and amphotericin B were 7.05,
10.7,47, and 0.6 µgr/ml, respectively after 48 hours incubating. Then, the
azole antifungal drugs were evaluated in combination with amphotericin B. The
two combinations of fluconazole + amphotericin and miconazole + amphotericin
with the Fungicidal Inhibitory Concentrations (FIC) of 0.6 and 1, respectively,
attracted the most attentions. In addition, comparing the antifungal effects,
the most effective drug was amphotericin B with the Minimum Fungicidal
Concentration (MFC) of 1.18.</span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal"><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Conclusion:</span></i></b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> In this study, amphotericin B with the least
MIC had the best antifungal effect. The most and the least synergic effects of
combination therapy were for fluconazole + amphotericin B and Miconazole +
amphotericin B, respectively.</span></p>
واژینیت کاندیدایی مزمن, همبست داروها, همافزایی, میکرودایلوشن براث, کلوتریمازول, مایکونازول, فلوکونازول, آمفوتریسینب
Chronic candidal vulvovaginitis, Drugs combination, Synergism, Micro dilution broth, Clotrimazole, Miconazole, Fluconazole, Amphotericin B
327
334
http://jabs.fums.ac.ir/browse.php?a_code=A-10-29-2&slc_lang=fa&sid=1
Efate alsadat
shojaei
عفت السادات
شجاعی
10031947532846005649
10031947532846005649
No
Department of Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی ایران، تهران، ایران.
Mehraban
Falahati
مهربان
فلاحتی
mehrabanfalahati@yahoo.com
10031947532846005650
10031947532846005650
Yes
Department of Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی ایران، تهران، ایران.
Faride
zaini
فریده
زینی
science.fzaini@tums.ac.ir
10031947532846005651
10031947532846005651
No
Department of Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی ایران، تهران، ایران.
Parivash
kord bache
پریوش
کرد بچه
pkordbache@sina.tums.ac.ir
10031947532846005652
10031947532846005652
No
Department of Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی ایران، تهران، ایران.
Parvaneh
rahimi moghadam
پروانه
رحیمی مقدم
10031947532846005653
10031947532846005653
No
Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran.
گروه فارماکولوژی، دانشگاه علوم پزشکی ایران، تهران، ایران.
Mohammad reza
aghamirian
محمد رضا
آقامیریان
Aghamirian 2001@yahoo.com
10031947532846005654
10031947532846005654
No
Department of Parasitology and Mycology, Qazvin University of Medical Sciences.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی قزوین، قزوین، ایران.
Shima
Nozari
شیما
نوذری
shimanozari@yahoo.com
10031947532846005655
10031947532846005655
No
Department of Parasitology and Mycology, Bandar Abbas University of Medical sciences
گروه انگل شناسی و قارچ شناسی دانشگاه علوم پزشکی بندر عباس، بندرعباس، ایران.
Ayesheh
Makhdoomi
عایشه
مخدومی
s.ameri 1360 @yahoo.com
10031947532846005656
10031947532846005656
No
Department of Parasitology and Mycology, Qazvin University of Medical Sciences.
شرکت داروسازی بهوزان، تهران، ایران.
Sekhavatv
ameri
سخاوت
عامری
Sciences.sasfshar@yahoo.com
10031947532846005657
10031947532846005657
No
Department of Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی ایران، تهران، ایران.
Sanam
afshar moghadam
صنم
افشار مقدم
10031947532846005658
10031947532846005658
No
Department of Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran.
گروه انگل شناسی و قارچ شناسی، دانشگاه علوم پزشکی ایران، تهران، ایران.