Journal of Advanced Biomedical Sciences

fa اثرضد باکتریایی آلیسین، نانوذرات نقره و ترکیب آن‌ها علیه عفونت پوستی سودوموناس آئروژینوزا درمدل حیوانی Antibacterial Effect of Allicin, Silver Nano Particles, and Their Combination against Skin Infection due to Pseudomonas aeruginosa in Animal Model ميكروبیولوژی Microbiology پژوهشي Research <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">زمینه و هدف<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">:<a name="OLE_LINK9"></a><a name="OLE_LINK26"></a><a name="OLE_LINK27"> </a><span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">به دلیل مقاومت باکتری‌ها، <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">آنتی بیوتیک‌های معمول ممکن است در برابر عوامل بیماری‌زای چند مقاومتی بی‌فایده باشند. <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">استفاده از<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">فناوری نانو و ترکیبات موثر گیاهان<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">، <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">می‌تواند راهکار مناسبی <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">برای حل این مشکل<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">باشند.<a name="OLE_LINK33"></a><a name="OLE_LINK34"> </a><span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">هدف از تحقیق حاضر بررسی<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">خاصیت <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">ضد میکروبی آلیسین، نانوذرات نقره و <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">ترکیب آن‌ها علیه<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">عفونت پوستی ناشی از سودوموناس آئروژینوزا در مدل حیوانی می‌باشد<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">.<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">موادوروش‌ها<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">:<a name="OLE_LINK12"></a><a name="OLE_LINK13"></a><a name="OLE_LINK6"></a><a name="OLE_LINK7"> </a><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">در این مطالعه تجربی، حداقل غلظت ممانعت از رشد<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> MIC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و حداقل غلظت کشنده باکتری<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> MBC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">برای آلیسین،<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نانو ذرات نقره<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و ترکیب آن‌ها<a name="OLE_LINK15"></a><a name="OLE_LINK14"><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </a><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">با روش ماکرودیلوشن تعیین شد. در ناحیه کتف 12سر موش سوری، عفونت پوستی با استفاده از باکتری<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">سودوموناس آئروژینوزا<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">ایجاد شد و اثر آلیسین، نانوذرات نقره و اثر ترکیب<a name="OLE_LINK16"></a><a name="OLE_LINK17"><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </a><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">آن‌ها به صورت پماد بر روی عفونت ایجاد شده بررسی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">گردید<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">.<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نتایج<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">: MIC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> MBC<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">آلیسین بر<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">رویسودوموناس آئروژینوزا <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">به ترتیب 38/2 و 77/4<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">میلی گرم برمیلی لیتر و<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> MIC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">وMBC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نانو ذرات نقره<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">به <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">ترتیب<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">12/3 <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و 25/6ppm <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">بودند<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">. MIC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> MBC <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">ترکیب آلیسین و نانوذرات نقره بر روی باکتری<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">سودوموناس آئروژینوزا<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">به ترتیب 59/0<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">میلی گرم بر میلی لیتر و 5/1<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> ppm<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">، <span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">19/1 <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">میلی گرم بر میلی لیتر و 12/3<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> ppm<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">بودند<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">. <a name="OLE_LINK37"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">مطالعه مدل حیوانی اثر ضدمیکروبی آلیسین، نانوذرات نقره و اثر هم افزایی ترکیب آلیسین و</a><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نانوذرات نقره را<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">بر علیه عفونت پوستی ناشی از سودوموناس آئروژینوزا تایید کرد<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">.<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نتیجه‌گیری<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">:<a name="OLE_LINK30"></a><a name="OLE_LINK21"> </a><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">ترکیب آلیسین و نانوذرات نقره دارای اثر هم افزایی علیه عفونت پوستی ناشی از باکتری<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">سودوموناس آئروژینوزا<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">می‌باشد<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">. Background & Objective: Common antibiotics may be useless against multiple pathogens because of the multidrug resistance. Therefore, new ways of nanotechnology and effective herbal combination can be the solution for this problem. The objective of this study is to investigate the antimicrobial effect of Allicin, silver nano particles and their combination against skin infection due to Pseudomonas aeruginosa in animal model.Materials & Methods: In this experimental study, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Allicin, silver nano particles, and their combination were determined by macro dilution susceptibility test. Skin infection was produced in the shoulder region of 12 mice using Pseudomonas aeruginosa and the effect of ointment of Allicin, silver nano particles, and their combination were evaluated. Results: The results showed that MIC and MBC of Allicin for pseudomonas aeruginosa were 2.38 and 4.77 mg/ml, respectively. MIC and MBC of silver nano particle for Pseudomonas aeruginosa were 3.12 and 6.25 ppm, respectively. MIC and MBC of combination of Allicin and silver nano particles on Pseudomonas aeruginosa were 0.59 mg/ml and 1.5 ppm, 1.19 mg/ml and 3.12 ppm, respectively. Anti-microbial effect of Allicin, silver nano particles and the synergistic activity of their combination against skin infections due to Pseudomonas aeruginosa was observed in animal model.Conclusion: The results showed that Allicin in combination with silver nano particles have synergistic effect against skin infection due to Pseudomonas aeruginosa. عفونت پوستی, سودوموناس آئروژینوزا, آلیسین, نانوذرات نقره, اثر هم افزایی Skin Infection, Pseudomonas aeruginosa, Allicin, silver Nanoparticles, Synergistic Effect 311 317 http://jabs.fums.ac.ir/browse.php?a_code=A-10-53-1&slc_lang=fa&sid=1 Fatemeh Mirzaei فاطمه میرزایی 10031947532846005641 10031947532846005641 No Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran. دانشگاه آزاد اسلامی، واحد زنجان، گروه میکروبیولوژی، زنجان، ایران. Mojtaba Salouti مجتبی صلوتی saloutim@yahoo.com 10031947532846005642 10031947532846005642 Yes Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran. دانشگاه آزاد اسلامی، واحد زنجان، مرکز تحقیقات بیولوژی، زنجان، ایران. Reza Shapouri رضا شاپوری 10031947532846005643 10031947532846005643 No Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran. دانشگاه آزاد اسلامی، واحد زنجان، مرکز تحقیقات بیولوژی، زنجان، ایران. Hamed Alizadeh حامد علیزاده 10031947532846005644 10031947532846005644 No Young Researchers and Elite Club, Zanjan Branch, Islamic Azad University, Zanjan, Iran. دانشگاه آزاد اسلامی، واحد زنجان، باشگاه پژوهشگران جوان و نخبگان، زنجان، ایران.