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The Effect of Propofol Anesthesia on Cutaneous Wound Healing in Rats
Alireza Raayat Jahromi, Abutorab Tabatabaei Naeini, Nader Tanideh, Pegah Banan,
Volume 6, Issue 3 (11-2016)
Abstract

Background & Objective: The present study surveys the effects of propofol on cutaneous wound healing in rats.

Materials & Methods: 36 adult female Strague-Dawely rats were divided into three groups randomly; in group one propofol (60 mg/kg) and ketamine (40 mg/kg) combination; in group two ketamine (50 mg/kg), and in group three propofol (100 mg/kg) was injected intraperitoneally. Following routine surgical preparation, 1.5×1.5 cm wounds were created on the back of the rats. Wound size was evaluated daily and then the wound area was calculated by Digimizer software. Following euthanasia on day 21 after wounding, 1×1 cm skin samples were collected for histopathological evaluations and hydroxyproline content.

Results: Wound size and hydroxyproline content showed no significant difference in propofol group compared to ketamine and propofol-ketamine groups. Fibroblast content and vascularity revealed no significant difference between groups. Inflammatory cell infiltration in ketamine group, collagen deposition in ketamine-propofol groups, and epithelial regeneration in propofol group were significantly higher in comparison with others.

Conclusion: In conclusion, single use of propofol has no adverse effect on cutaneous wound healing in rats compared to ketamine, but evaluation of its positive effects on wound healing necessitates more detailed studies.


The Effect of Vertical Sleeve Gastrectomy on Weight Loss, Insulin and Glucose Levels in Dogs
Parham Razavi Ebrahimi, Aboutorab Tabatabaei Naeini, Alireza Raayat Jahromi, Masood Amini, Afshin Zare,
Volume 12, Issue 1 (3-2022)
Abstract
Background & Objective: This study was designed to evaluate the effect of sleeve-gastrectomy procedure on weight loss, glucose and insulin blood levels in overweight dogs.
Materials & Methods: In the current study, 5 overweight dogs (31.6±3.03kg) were selected for sleeve-gastrectomy procedure. Insulin and glucose levels were measured from the blood samples that were taken before the surgery and weekly 1.5 month post-operatively. The weight of the dogs was also measured at the same time. The surgery was performed according to the technique described by Gagner 2009, and the dogs received special diet during the recovery period to end of the study.
Results: One dog died due to dehiscence and leakage 48 hours post-operatively. Decrease in mean weight was 6.25±0.44 in the first week after surgery and the weight loss process continued to end of the study. Changes in insulin and glucose blood levels demonstrated to have pulsatile patterns. Insulin levels decreased for the first week, but its level increased in the second week period. Again, insulin levels demonstrated to have decreasing pattern in the following 4 weeks. On the other hand, the glucose levels changed each week and did not show any certain pattern.
Conclusion: Post-operative weight loss was observed in all cases but it was not statistically significant. It could be due to limited number of the samples. The glucose and insulin changes were attributed to hormonal changes particularly gut hormones that were affected by sleeve-gastrectomy procedure but further detailed studies on hormonal effect are required.
 

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