Journal of Advanced Biomedical Sciences
JABS
Tue, Apr 29, 2025
[Archive]
Shirin Hajimazdarani1 
, Shahin Mohammadsadeghi1 , Naser Mozafari1 , Keshvad Hedayatyanfard2 , Neda Baghban3 , Hasan Habibi *4
, Shahin Mohammadsadeghi1 , Naser Mozafari1 , Keshvad Hedayatyanfard2 , Neda Baghban3 , Hasan Habibi *4
1- Plastic Surgery Ward, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
3- Food Control Laboratory, Food and Drug Deputy, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Animal Scinces, Agricultural and Natural Resources College, Persian Gulf University, Bushehr, Iran ,dr.h.habibi@gmail.com
2- Department of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
3- Food Control Laboratory, Food and Drug Deputy, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Animal Scinces, Agricultural and Natural Resources College, Persian Gulf University, Bushehr, Iran ,
Abstract: (60 Views)
Background & Objectives: This study aimed to evaluate the efficacy of chitosan gel infused with the hydroalcoholic extract of Moringa oleifera leaf powder in promoting wound healing and reducing scar formation following cosmetic breast surgery.
Materials & Methods: A total of 42 patients undergoing cosmetic breast surgery were enrolled in this randomized controlled study. Each patient’s breast was divided into two lateral hemispheres: one side received Moringa oleifera gel, while the other served as a control with a placebo gel. The gels were applied for two weeks postoperatively. Scar appearance was assessed at two weeks and three months post-surgery using the Vancouver Scar Scale (VSS), which evaluates vascularity, pigmentation, elasticity, and height. Data were analyzed to compare outcomes between the treated and control sites.
Results: Of the initial 42 patients, 36 completed the study. Twenty-five and thirty-one patients were evaluated at the two-week and three-month follow-ups, respectively. Wounds treated with the Moringa-infused gel demonstrated an 84% improvement in healing compared to those treated with the placebo. Statistically significant improvements were observed in all evaluated parameters—including vascularity, pigmentation, height, and elasticity—in favor of the Moringa oleifera gel.
Conclusions: Chitosan gel infused with the hydroalcoholic extract of Moringa oleifera leaf powder significantly enhances wound healing and improves scar appearance following cosmetic breast surgery. These findings highlight its potential as a valuable adjunct in postoperative wound care for reducing scarring and promoting tissue regeneration.
Keywords:
Materials & Methods: A total of 42 patients undergoing cosmetic breast surgery were enrolled in this randomized controlled study. Each patient’s breast was divided into two lateral hemispheres: one side received Moringa oleifera gel, while the other served as a control with a placebo gel. The gels were applied for two weeks postoperatively. Scar appearance was assessed at two weeks and three months post-surgery using the Vancouver Scar Scale (VSS), which evaluates vascularity, pigmentation, elasticity, and height. Data were analyzed to compare outcomes between the treated and control sites.
Results: Of the initial 42 patients, 36 completed the study. Twenty-five and thirty-one patients were evaluated at the two-week and three-month follow-ups, respectively. Wounds treated with the Moringa-infused gel demonstrated an 84% improvement in healing compared to those treated with the placebo. Statistically significant improvements were observed in all evaluated parameters—including vascularity, pigmentation, height, and elasticity—in favor of the Moringa oleifera gel.
Conclusions: Chitosan gel infused with the hydroalcoholic extract of Moringa oleifera leaf powder significantly enhances wound healing and improves scar appearance following cosmetic breast surgery. These findings highlight its potential as a valuable adjunct in postoperative wound care for reducing scarring and promoting tissue regeneration.
Keywords:
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)