en تاثیر نانوذرات نقره تولید شده توسط عصاره گیاه دارویی کرفس بر آزمون های عملکردی کلیه گیاهان دارویی Pharmaceutical Plants پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f497d">Background & Objectives:</span></span></span></b> <i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Kelussia odoratissima </span></span></i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">is involved in the treatment of kidney stones, irritation of the urinary tract and kidney and bladder cleansing. It is useful for gout patients and is used to treat kidney and ureteral stones. The aim of this study was to investigate the effect of <i>Kelussia odoratissima </i>on renal function tests in male rats.<i></i></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f497d">Materials & Methods:</span></span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">In this study, 20 rats were randomly divided into one control group and three treatment groups (n=5 per group). The treatment groups received a 40, 80, and 120 mg/kg silver nanoparticles produced by the extracts of <i>Kelussia</i>, orally once a day for 6 days. After taking a blood sample, a kidney function test was performed. SPSS software version 21 was used for data collection, and the results were presented as mean and standard deviation (mean&plusmn;SEM).</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f497d">Results:</span></span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Oral administration of silver nanoparticles produced by <i>Kelussia </i>extracts at 80 mg/kg dose significantly reduced bilirubin and urea compared to the control group (P<0.05). The 120 mg/kg dose also significantly reduced urea compared to the control group (P<0.05). There was no significant effect on total protein, albumin and urea. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f497d">Conclusion:</span></span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Silver nanoparticles produced by the <i>Kelussia </i>extracts did not show any negative effect on kidney function, but had some positive effect on waste removal.</span></span><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f497d"></span></span></span></b></span></span></span></span></div> Kelussia, Kidney, Rat 21 26 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2377-3&slc_lang=en&sid=1 Nezam Armand نظام آرمند armandnezam@ut.ac.ir 100319475328460028411 100319475328460028411 No Research Center for Herbal Medicine and Complementary Medicine, Alborz University of Medical Sciences, Karaj, Iran مرکز تحقیقات گیاه پزشکی و طب مکمل، دانشگاه علوم پزشکی البرز، کرج، ایران Hassan Morovvati حسن مروتی hmorovati@ut.ac.ir 100319475328460028412 100319475328460028412 Yes Department of Basic Science, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran گروه علوم پایه، دانشکده دامپزشکی، دانشگاه تهران، تهران، ایران Yaser Azizi یاسر عزیزی aziziy@iums.ac.ir 100319475328460028413 100319475328460028413 No Physiology Research Center, Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran مرکز تحقیقات فیزیولوژی، گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران