[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 3, Issue 1 (Spring 2013) ::
JABS 2013, 3(1): 1-8 Back to browse issues page
Assessment of Culture Condition and In Vitro Colonization Ability of Human Spermatogonial Stem Cells: A Review Article
Maryam Mahal Dashtian, Zohreh Makoolati 1, Mohammad taghi Ghorbanian, Majid Naghdi
1- , zohreh1438@yahoo.com
Abstract:   (37839 Views)

Spermatogenesis is a highly complex and regulated process in which germ stem cells differentiate into spermatozoa. These stem cells, called spermatogonial stem cells (SSCs), are in the base of seminiferous tubules and have the ability of self-renewal and differentiation into functional germ cells. Due to this ability, SSCs can restore spermatogenesis after testicular damage caused by cytotoxic materials or following transplantation into an infertile recipient. Therefore, self-renewal of these cells is critical for the preservation of SSC populations and restoration of fertility. While previous studies have shown that the SSCs of mice and other species can survive and proliferate for long periods of time, little information is available about suitable culture media for the growth of human SSCs. Identification of SSC markers allows for the isolation of these populations of cells. The isolated cell can be expanded in culture and transplanted into infertile recipients. Consequently, the recognition of markers and the establishment of long-term culture systems for human SSCs will be essential for using the potential of these cells in a clinical setting. In this article, we focus on the markers that have been identified for human SSCs and in vitro culture techniques used for human SSCs proliferation.

Keywords: Spermatogonial stem cells, Colony, Self-renewal
Full-Text [PDF 560 kb]   (5807 Downloads)    
Type of Study: Review | Subject: Histology
Received: 2012/12/25 | Accepted: 2013/02/24 | Published: 2013/09/14
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mahal Dashtian M, Makoolati Z, Ghorbanian M T, Naghdi M. Assessment of Culture Condition and In Vitro Colonization Ability of Human Spermatogonial Stem Cells: A Review Article. JABS. 2013; 3 (1) :1-8
URL: http://jabs.fums.ac.ir/article-1-214-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (Spring 2013) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4343