Journal of Advanced Biomedical Sciences

fa مقایسه فعالیت آلفا-1-آنتی تریپسین در افراد چاق با افراد دارای وزن طبیعی Comparison The Activity Rate of Alpha-1 Antitrypsin in Obese with normal weight People بيوشيمي بالینی Biochemistry پژوهشي Research   Background & Objective: Obesity is one of the most important global health priorities as far as it increases illnesses and disorders the life quality. Alpha-<a href="https://rdiet.ir/">1</a>-Antitrypsin (AAT) is the most abundant serum protease inhibitor and prevents tissue degradation through proteases. Hence, its defect or deficiency significantly increases the risk of various diseases. AAT may be involved in the development and complications of obesity. The present study then was performed to determine the activity of AAT in the obese people compared to those with normal weight.   Materials & Methods: In this cross- sectional study, determining the AAT’s activity was performed through Trypsin-Inhibitor-Capacity (TIC) in healthy individual who were referred to the laboratory of Dr.Shariati in Fasa Hospital in April 2013.   Serum of 150 people with normal weight (Body Mass Index, BMI, ranges between 18.5 and 24.9) and the serum of 140 obese people (BMI more than 30) were surveyed. The data were analyzed by SPSS software using t-test and Pearson correlation coefficient.   Results: The serum amount of TIC in obese people (1.774±0.618 µmol/min/ml) was significantly lower than its amount in people with normal weight (3.047±0.498 µmol/min/ml) (P-value< 0.001). There was a significant negative correlation between TIC and weight (P< 0.001, R=-0.686). In addition, no significant correlation was observed between TIC and age sex and height.   Conclusion: The results showed that AAT in obese people was less in healthy individuals compared with the ones with normal weight. Therefore, it can be stated that AAT can be introduced as a clinical biomarker and be a potential target for treating obesity.     Obesity, alpha-1 antitrypsin, trypsin inhibitory capacity. 134 140 http://jabs.fums.ac.ir/browse.php?a_code=A-10-452-2&slc_lang=fa&sid=1 farzad roshanzamir فرزاد روشن ضمیر farzad.roshanzamer@yahoo.com 2410979483 100319475328460024278 No دانشگاه علوم پرشکی فسا alireza khoshdel علیرضا خوشدل Alireza.khoshdel@gmail.com 100319475328460024279 100319475328460024279 Yes دانشگاه علوم پرشکی رفسنجان mehdi mahmoodi مهدی محمودی 100319475328460024280 100319475328460024280 No دانشگاه علوم پرشکی رفسنجان mohamadrezad hajizade محمدرضا حاجی زاده 100319475328460024281 100319475328460024281 No دانشگاه علوم پرشکی رفسنجان mohsen rezaeian محسن رضاییان 100319475328460024282 100319475328460024282 No دانشگاه علوم پرشکی رفسنجان Giti Farsi گیتی فارسی 100319475328460024283 100319475328460024283 No دانشگاه علوم پرشکی رفسنجان rezvan bizhani رضوان بیژنی 100319475328460024284 100319475328460024284 No دانشگاه علوم پرشکی فسا mohamadmehi naghizade محمد مهدی نقی زاده 100319475328460024285 100319475328460024285 No