fa اثر مکمل ال آرژنین بر پروفایل لیپیدی بیماران مبتلا به دیابت نوع 2 تغذيه Nutrition پژوهشي Research <p> <strong><font face="Times New Roman" size="3"> </font><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">زمینه و هدف:</span><span lang="FA" style="font-family: "B Nazanin" font-size: 12pt font-style: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"> </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">رشد چشمگیر آمار مبتلایان به دیابت ملیتوس و خطر عوارض آن، لزوم تمرکز بر یافتن راه­های جدید کنترل آن را مطرح می­نماید.</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="font-family: "Times New Roman","serif" font-size: 8pt font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">مطالعه حاضر به منظور بررسی اثر مکمل یاری </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">L-Arginine</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> بر پروفایل لیپیدها در بیماران دیابت نوع2 انجام شد.</span></strong></p><p class="1" style="margin: 1em 0px line-height: normal" dir="rtl"><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">مواد و روش‌ها:</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"> در یک کارآزمایی بالینی تصادفی شده دوسوکور 75 بیمار مبتلا به دیابت نوع 2 به طور تصادفی به سه گروه تقسیم شدند. 1) 3‌گرم ال آرژنین در روز 2) 6‌گرم ال آرژنین در روز و 3)گروه دارونما تقسیم شدند. قد،</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="font-family: "Times New Roman","serif" font-size: 8pt font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">وزن، دور کمر،</span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">HDL </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: normal mso-bidi-font-style: italic">‌، </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">TG</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: normal mso-bidi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">LDL</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> و کلسترول تام قبل و بعد از 3</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="font-family: "Times New Roman","serif" font-size: 8pt font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">ماه مداخله اندازه گیری شد.</span></p><p class="1" style="margin: 1em 0px line-height: normal" dir="rtl"><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">نتایج:</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"> در گروه مداخله یک تغییر معناداری در هیچ یک از پیراسنج­های چربی ایجاد نشد (</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>0.05</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: normal mso-bidi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span><</span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">P-value</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: normal mso-bidi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span>).</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"> اما در گروه مداخله 2 میانگین کلسترول از 34،83</span><span lang="FA" style="font-family: "Cambria","serif" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ansi-font-style: italic mso-bidi-font-family: Cambria">±</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">169،12 به </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">mg/dl</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> 32،13</span><span lang="FA" style="font-family: "Cambria","serif" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ansi-font-style: italic mso-bidi-font-family: Cambria">±</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">142،08 </span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>(p-value<0.001</span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr">)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> و </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">LDL</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> از </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">mg/dl</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> 35،46</span><span lang="FA" style="font-family: "Cambria","serif" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ansi-font-style: italic mso-bidi-font-family: Cambria">±</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">96،80 به 32،65</span><span lang="FA" style="font-family: "Cambria","serif" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ansi-font-style: italic mso-bidi-font-family: Cambria">±</span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">86،64 </span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>(p-value=0.001)</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-family: "B Nazanin" font-size: 10pt font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: normal mso-bidi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">کاهش یافت هر چند تغییرات ایجاد شده در </span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">TG</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> و</span><span style="font-family: "Times New Roman","serif" font-size: 8pt font-style: normal font-weight: normal mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-style: italic" dir="ltr">HDL</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"><span dir="rtl"></span><span dir="rtl"></span> معنادار نبود.</span></p><p class="1" style="margin: 1em 0px line-height: normal" dir="rtl"><a name="_Toc377996915"><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">نتیجه‌گیری:</span></a><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic"> </span><span lang="FA" style="font-family: "B Nazanin" font-size: 10pt font-style: normal font-weight: normal mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-style: italic">مصرف روزانه 6 گرم ال آرژنین به مدت 3 ماه در بیماران دیابت نوع2 می‌تواند منجر به بهبود پروفایل لیپیدی گردد اما دوز 3 گرم در روز این مکمل اثری بر وضعیت چربی­های خون ندارد. <o:p /></span></p><p><font face="Times New Roman" size="3"> </font></p> <p> <strong>Background & Objective:</strong> The prominent growth in the statistics of the patients with Diabetes Mellitus (DM) and the danger of its complication states a necessity to focus on finding new ways to control it. The present study then was performed to survey the effect of L-Arginin supplementation on the metabolism of sugar and lipid profiles in patients with diabetes type 2. </p><p><strong>Materials & Methods:</strong> In a randomized double-blind clinical trial, 75 patients with diabetes type 2 were divided into three groupsrandomly: 1. 3 gr L-Arginin per day, 2. 6 gr L-Arginin per day and 3. The placebo group. Height, weight, waist, High Density Lipoprotein (HDL), Triglycerides (TG), Low Density ipoprotein (LDL), and the total cholesterol were measured before and after three months of intervention. </p><p><strong>Results:</strong> no significant change was made in any of the lipid parameters in the intervention group. However, the two means of cholesterol and LDL decreased from169.12±34.83 mg/dl to 142.08±32.13mg/dl(P-Value<0.001) and from 96.80±35.46mg/dl to 86.64±32.65(P-Value=0.001), respectively though The changes in TG and HDL were not significant. </p><p><strong>Conclusion:</strong> Daily consumption of six gram L-Arginin during three months improves the lipid profiles in patients with Diabetes type2. Nevertheless, the dosage of three gram in a day of this supplement has no effect on the blood lipids status. </p> ال آرژنین,‌ دیابت, پروفایل لیپیدی Garlic, lead, kidney, rat. 99 110 http://jabs.fums.ac.ir/browse.php?a_code=A-10-557-1&slc_lang=fa&sid=1 sara asadi سارا اسدی asadis_744@yahoo.com 2572342421 10031947532846004605 Yes Fasa University of Medical Sciences دانشگاه علوم پزشکی فسا hasan mozaffari khosravi حسن مظفری خسروی mozaffari@ssu.ac.ir 10031947532846004606 10031947532846004606 No Shahid Sadoughi University of Medical Sciences-Yazd دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد MahnazMehdi Rahimi مهناز رحیمی mmnaghi@gmail.com 10031947532846004607 10031947532846004607 No Fasa University of Medical Sciences دانشگاه علوم پزشکی فسا Mohammad Mehdi Naghizadeh محمدمهدی نقی زاده farzaneasadi@gmail.com 10031947532846004608 10031947532846004608 No Shiraz University of Medical Science داشگاه علوم پزشکی شیراز