en اثرات محافظت نورونی عصاره پوست بادام زمینی (Arachis hypogaea) در مدل موش صحرایی مبتلا به ایسکمی-ریپرفیوژن مغزی فراگیر: ارزیابی رفتاری، بیوشیمیایی و بافت‌شناسی فيزيولوژي Physiology پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><u><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Background & Objectives:</span></span></span></u> </strong>Stroke is a major consequence of cerebral ischemia.<span new="" roman="" style="font-family:" times=""> This study investigated the effects of peanut skin extract (PSE) (or <i>Arachis hypogaea</i>) on behavioral, biochemical, and histological parameters of the hippocampus in rats subjected to global ischemia-reperfusion (I/R).</span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><u><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Materials & Methods:</span></span></span></u> </strong>&nbsp;<span new="" roman="" style="font-family:" times="">In this experimental study, adult male Wistar rats were assigned to the following groups: control (no I/R and no manipulation; received 0.9% saline), sham (no I/R; surgical site opened; received 0.9% saline), PSE (100 mg/kg), I/R, and I/R + PSE (10 and 100 mg/kg). Ischemia was induced by bilateral occlusion of the common carotid arteries for 20 minutes, followed by 24 hours of reperfusion. PSE was extracted using the maceration method and was administered following 24 hours of ischemia induction and then given daily for 1 week. Anxiety-like behavior, pain perception, and recognition memory were assessed after the final injection. Hippocampal microscopic structure and acetylcholinesterase (AChE) activity and serum oxidative stress markers were measured.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><u><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Results:</span></span></span></u> </strong>PSE improved anxiety-like behavior, pain perception, and recognition memory in I/R rats (P < 0.05).<span new="" roman="" style="font-family:" times=""> I/R decreased superoxide dismutase (SOD) and glutathione reductase (GR) activities (both P < 0.001) and increased serum (P < 0.05) and hippocampal AChE activity (P < 0.01). PSE treatment decreased GSSG levels and AChE activity (P < 0.01) and increased catalase activity (P < 0.01). PSE treatment reduced the percentage of dead pyramidal cells in the hippocampal CA1 region of I/R rats (P < 0.05).<span style="font-weight:normal"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><u><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Conclusion:</span></span></span></u> </strong><span new="" roman="" style="font-family:" times="">PSE appears to exert neuroprotective effects, likely by reducing oxidative stress markers and attenuating histopathological damage in the hippocampus.</span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></div> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span>  Anxiety, Antioxidants, Ischemia-Reperfusion, Pain, Arachis hypogaea, Peanut skin 274 290 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3402-2&slc_lang=en&sid=1 Leila Khangah لیلا خانگاه leila.khangah1989@gmail.com 100319475328460030338 0009-0002-2888-1498 No Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran گروه زیست‌شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران Mahnaz Kesmati مهناز کسمتی m.kesmati@scu.ac.ir 100319475328460030339 100319475328460030339 Yes Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran گروه زیست‌شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران Ali Shahriari علی شهریاری a.shahriari@scu.ac.ir 100319475328460030340 100319475328460030340 No Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran گروه علوم پایه، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران Mehran Dorostghoal مهران درست قول dorostghoal@gmail.com 100319475328460030341 100319475328460030341 No Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran گروه زیست‌شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران Mozhgan Torabi مژگان ترابی m.torabi@scu.ac.ir 100319475328460030342 100319475328460030342 No Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran گروه زیست‌شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران