en ارتباط RNA های طولانی غیر کد کننده (Lnc-RNA) با پیشرفت سرطان کولورکتال انكولوژي Oncology مروری Review <div style="text-align: justify;"><span style="font-size:12pt"><span new="" roman="" style="font-family:" times="">Colorectal cancer (CRC) is the third most prevalent cancer worldwide and represents a significant public health concern. Given its complexity, further research is needed to elucidate the role of signaling pathways, particularly those involving long non-coding RNAs (LncRNAs). LncRNAs, which are non-coding RNAs exceeding 200 nucleotides in length, are transcribed by RNA polymerase II and play a crucial role in gene regulation. Altered expression of LncRNAs has been implicated in multiple diseases, including CRC, where they affect key cellular signaling pathways. In this regard, the upregulation of <em>C6ORF176, CASC9er35e, ESCCAL-1, FBXL19-AS1, FGD5-AS1, FOXD3-AS1, LBX2-AntisenseRNA1, SLCO4A1-AS1,</em> and <em>HOTAIRM1</em>, as well as the downregulation of <em>RP11-462C24.1</em> and <em>RPL34-AS1</em>, has been linked to CRC progression. The urgency of CRC screening is underscored by its increasing incidence, with 14% of cases diagnosed in individuals under 50 years of age in 2021 and 40&ndash;45% of cases reported in adults in 2020 and in 2022, according to the Global Cancer Observatory (GLOBOCAN), there has been 1.14 million new diagnosed colon cancer and this number is projected to reach 1.99 million by 2050. Moreover, the annual global incidence surpasses 1.9 million new cases, particularly in Europe, Oceania, and North America. The development and spread of CRC may be mitigated by targeting key pathways such as cAMP/CREB, AKT/mTOR/EMT, Wnt/&beta;-catenin, and nuclear factor (NF)-&kappa;B. In this review, we provide a comprehensive summary of novel LncRNAs associated with CRC, focusing on those that have been relatively underexplored. Our findings highlight their potential as both therapeutic targets and research tools, contributing to selective treatment strategies and further investigations aimed at expanding our understanding of CRC pathogenesis.</span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> &nbsp;</div> Colorectal cancer, Long non-coding RNAs (LncRNA), Oncogenesis, Biomarkers 19 36 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3413-1&slc_lang=en&sid=1 Mohammad Javad Tahmasebi محمدجواد طهماسبی mohammadjtah76@yahoo.com 100319475328460029706 100319475328460029706 No Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran گروه بیوشیمی بالینی، دانشگاه علوم پزشکی فسا، فسا، ایران Azam Khedri اعظم خدری azamkh1317@gmail.com 100319475328460029707 100319475328460029707 No Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia, United States گروه بیوشیمی، دانشکده پزشکی، دانشگاه اموری، آتلانتا، جورجیا، ایالات متحده آمریکا Behnoosh Miladpour بهنوش میلادپور miladpour90@yahoo.com 100319475328460029708 100319475328460029708 Yes Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran گروه بیوشیمی بالینی، دانشگاه علوم پزشکی فسا، فسا، ایران