en ايمونولوژي Immunology مروری Review <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#050e17">The pancreas is an organ that&nbsp;conducts exocrine and endocrine&nbsp;activities in the body and plays an important role in digestive system and blood glucose regulation. Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is one of the most serious illnesses of this organ, killing many individuals each year due to the absence of an early detection method, making this cancer the </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">third </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#050e17">leading cause of death among malignancies. In up to 90% of cases, genetic abnormalities such as <i>KRAS</i> mutations and mutations in tumor suppressors such as <i>CDKN2A</i>, <i>TP53</i>, and <i>SMAD4</i> can be detected, indicating the significance of additional studies in genetic diagnosis and therapy for this cancer. In this review, in addition to discovering information about the pancreas and its role in the body, an attempt has&nbsp;been&nbsp;made to determine the genetic origin of this malignancy. In addition, special consideration has been given to current therapeutic approaches and gene therapy-based therapies.</span></span></span></span></span></span><br> &nbsp;</div> Pancreatic Ductal Adenocarcinoma, Suppressor Proteins, Gene therapy, Targeted Therapy 1 18 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1709-18&slc_lang=en&sid=1 Mahdi Mokhtari Tabar مهدی مختاری تبر majidghasemian86@gmail.com 100319475328460029703 100319475328460029703 No Department of Biochemistry, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Mohammad Ghorbani محمد قربانی 100319475328460029704 100319475328460029704 No Department of Hematology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه هماتولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Abdolmajid Ghasemian عبدالمجید قاسمیان majidghasemian86@gmail.com 100319475328460029705 100319475328460029705 Yes Non-Communicable Diseases Research ‏Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران