Journal of Advanced Biomedical Sciences

en Investigation of Lupus Nephritis Cases with Special Reference to Activity and Chronicity Indices پاتولوژي Pathology پژوهشي Research <div style="text-align: justify;">Background & Objectives: The International Society of Nephrology/ Renal Pathology Society (ISN/RPS) classification is based upon criteria which differentiate acute and chronic phases of Lupus Nephritis. Activity/Chronicity Index grants us a higher insight on the level of pathological lesions and treatment outcome by examining the reversibility of lesions .The present investigation was done in order to highlight the importance of activity and chronicity indices in the course of Lupus Nephritis. Materials & Methods: Seventy-three Kidney biopsy samples of Lupus Nephritis patients were examined. The information was recorded in a check-list and was then statistically analyzed. Results: Lupus Nephritis is importantly age-related, frequency of Lupus Nephritis increases with age until the age of 40 years; 21–40 years being the most frequent among studied patients. A prominent decline was seen after the age of 40. Regardless of age, the occurrence was more frequent in females. Class IV was most frequent in all ages and in both sexes. Both Activity and Chronicity scores were slightly higher in females. Activity Index was higher in ages of 11 to 30 years, whereas Chronicity Index was highest in 41 to 50 years of age. The highest Activity Index was reported in Class IV while the highest Chronicity Index was reported in Class V. The least Activity Index was shown in Class VI while Classes II and I had the lowest Chronicity Index. Endocapillary hypercellularity was the most frequent active lesion and tubular atrophy was the most frequent chronic lesion. It is noteworthy that fibrotic crescents were significantly less common among chronic lesions. Conclusion: Histopathological findings, clinical and para-clinical data could furnish more information on disease process, treatment, quality of life and mortality rate. </div> Lupus Nephritis, Activity Index, Chronicity Index, Histopathological features 92 101 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3238-1&slc_lang=en&sid=1 Khashayar Farshid خشایار فرشید khashayfar@gmail.com 100319475328460027538 100319475328460027538 Yes School of Medicine, Urmia University of Medical Sciences, Urmia, Iran دانشکده پزشکی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران Farahnaz Noroozinia فرحناز نوروزنیا fnoroozi@hotmail.com 100319475328460027539 100319475328460027539 No Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran گروه آسیب شناسی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران Masoumeh Pourjabali معصومه پورجبلی m.pourjabali@gmail.com 100319475328460027540 100319475328460027540 No Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran گروه آسیب شناسی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران