en بررسی دلایل تاثیر گذار در تولد فرزند تالاسمی در خانواده های دارای فرزند تالاسمی ماژور خون شناسی Hematology پژوهشي Research <div style="text-align: justify;"><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><a name="_Hlk109490262"><strong><span style="color:#2f5496">Background &&nbsp;Objectives:&nbsp;</span></strong></a><span style="color:#0e101a">Beta-thalassemia is one of the complex diseases that causes many social and economic problems for the patient and his family. This study aimed to investigate </span>factors influencing the birth<span style="color:#0e101a"> of thalassemia (intermedia or major) in family members with thalassemia major in Sistan and Baluchistan province. </span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span style="color:#2f5496">Materials & Methods:</span></strong> <span style="color:#0e101a">This descriptive-analytical study was conducted by census sampling on 48 families of thalassemia major patients with at least two children with thalassemia (intermedia or major) in their members. Data were collected through direct interviews and a review of patients&#39; documents. The results were analyzed by SPSS (version 22) and Mann-Whitney U, Independent t-test, Wilcoxon, and Chi-square tests.</span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span style="color:#2f5496">Results:&nbsp;</span></strong><span style="color:#0e101a">In this study, statistical evaluations showed that the birth of thalassemia in family members with thalassemia major whose mothers are housewives was 100% and in families that had no premarital counseling was 91.7%. There was a significant relationship between variables related to mothers&#39; awareness of thalassemia, including their place of residence and Sistani and Baluchestani ethnics, and the birth of thalassemia in family members with thalassemia major (in both cases, P-value = 0.05); However, there was no significant relationship between other variables related to mothers&#39; awareness such as age groups and maternal education with the birth of thalassemia in family members with thalassemia major (P-Value = 0.98 and P-Value = 0.22, respectively).<strong> </strong></span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span style="color:#2f5496">Conclusion:</span></strong><span style="color:#2f5496">&nbsp;<strong> </strong></span>Informing and educating before marriage for high-risk families with thalassemia children, as well as financial support for low-income families can inform parents, prevent the birth of thalassemia, and improve the quality of life of these patients.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span style="color:#0e101a"></span></strong></span></span><br> &nbsp;</div> Beta-Thalassemia, Awareness, Prenatal diagnosis 68 80 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3232-1&slc_lang=en&sid=1 Majid Naderi مجید نادری Mijid_naderi2000@yahoo.com 100319475328460027649 100319475328460027649 No Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران Sahar Najafi سحر نجفی Saharnajafi7772@gmail.com 100319475328460027650 100319475328460027650 No Department of Clinical Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran گروه علوم آزمایشگاهی بالینی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران Mohammad Hossein Ahmadi محمدحسین احمدی Ahmadi.hemato@gmail.com 100319475328460027651 100319475328460027651 No Department of Laboratory Sciences, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran گروه علوم آزمایشگاهی، دانشکده پیراپزشکی و توانبخشی، دانشگاه علوم پزشکی مشهد، مشهد، ایران Fariba Ramezani Siakhulak فریبا رمضانی 100319475328460027652 100319475328460027652 No Department of Epidemiology, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran گروه اپیدمیولوژی، مرکز تحقیقات ارتقای سلامت، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران Saeedeh Yaghoubi سعیده یعقوبی Yaghoubimd@yahoo.com 100319475328460027653 100319475328460027653 No Department of Pediatrics, Children and Adolescents Health Research Center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran گروه اطفال، مرکز تحقیقات سلامت کودکان و نوجوانان، پژوهشکده علوم سلولی و مولکولی بیماری‌های عفونی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران Younes Sadeghi-Bojd یونس صادقی Younessadeghibojd@gmail.com 100319475328460027654 100319475328460027654 Yes Department of Laboratory Sciences, School of Allied Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran گروه علوم آزمایشگاهی، دانشکده علوم پزشکی وابسته، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران