en مقایسه غلظت فیبرونکتین واژن و پلاسما برای پیش آگهی زایمان زودرس: یک مطالعه مقطعی بيوشيمي بالینی Biochemistry پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span lang="EN-IN" style="font-size:10.0pt">Background & Objective:</span></strong><span lang="EN-IN" style="font-size:10.0pt">&nbsp;Prediction of preterm delivery can reduce a large number of its complications. The present study aimed to compare vaginal and plasma fibronectin concentrations in the diagnosis of preterm delivery.</span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span lang="EN-IN" style="font-size:10.0pt">Materials & Methods:</span></strong><span lang="EN-IN" style="font-size:10.0pt">&nbsp;Serum samples were obtained from 105 women at 24-36 weeks of gestation. However, only 40 women gave permission to collect vaginal samples. Fibronectin concentration was measured using the ELISA technique. Then, plasma and vaginal fibronectin levels were compared in term and preterm deliveries.</span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span lang="EN-IN" style="font-size:10.0pt">Results:</span></strong><span lang="EN-IN" style="font-size:10.0pt">&nbsp;The mean plasma fibronectin level was 6226.43&plusmn;7174.97 ng/ml among the mothers with term infants and 7724.01&plusmn;1143.82 ng/ml among those with preterm infants (p=0.667). The mean fetal fibronectin level was 156.61&plusmn;126.42 ng/ml among the mothers with term infants and 127.71&plusmn;43.14 ng/ml among those with preterm infants (p=0.241). The cut-off point of plasma fibronectin level was 1750 ng/ml with a sensitivity of 80.25% and specificity of 85.17%. Additionally, the cut-off point of vaginal fibronectin level was 158.98 ng/ml with a sensitivity of 94.62% and specificity of 22.08%.</span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong><span lang="EN-IN" style="font-size:10.0pt">Conclusion:</span></strong><span lang="EN-IN" style="font-size:10.0pt">&nbsp;Plasma fibronectin analysis had lower sensitivity and higher specificity compared to vaginal fibronectin analysis. This implies that plasma testing has lower false-positive cases and can identify a more significant number of true positive cases of preterm delivery.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br> <br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></div> Premature Births, fibronectins, vaginal, plasma, Screening Tests 57 67 http://jabs.fums.ac.ir/browse.php?a_code=A-10-113-3&slc_lang=en&sid=1 Mohammad Hassan Meshkibaf محمدحسن مشکی باف meshkibaf2000@gmail.com 100319475328460027673 100319475328460027673 No Department of Biochemistry, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Zahra Moradi زهرا مرادی moradizahra427@yahoo.com 2571794922 100319475328460027674 Yes School of Nursing, Fasa University of Medical Sciences, Fasa, Iran دانشکده پرستاری، دانشگاه علوم پزشکی فسا، فسا، ایران Saeedeh Jafarzadeh سعیده جعفرزاده saeedeh.jafarzadeh@yahoo.com 100319475328460027675 100319475328460027675 No School of Nursing, Fasa University of Medical Sciences, Fasa, Iran دانشکده پرستاری، دانشگاه علوم پزشکی فسا، فسا، ایران Azizallah Dehghan عزیزاله دهقان dehghan.aziz@yahoo.com 100319475328460027676 100319475328460027676 No Non-communicable Diseases Research Center (NCDRC), Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران Ameneh Keshavarzi آمنه کشاورزی 100319475328460027677 100319475328460027677 No Department of Obstetrics and Gynecology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه زنان و زایمان، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران