en بررسی میزان استرادیول و انسولین در زنان مبتلا به سندرم تخمدان پلی کیستیک و ارتباط آن با شاخص توده بدنی بيوشيمي بالینی Biochemistry پژوهشي Research <div style="text-align: justify;"><strong><em>Background & Objective:</em></strong> &nbsp;Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, which is characterized by ovulatory dysfunction and hyperandrogenism.&nbsp;This study was done to evaluate insulin and estradiol (E2) in women with PCOS and its relationship with Body mass index (BMI).<br> <strong><em>Materials & Methods:</em></strong> This case-control study included, 104 women with polycystic ovary syndrome as a case group and 100 women without polycystic ovary syndrome as a control group. Concentrations of insulin, glucose and E2 were measured in fasting blood samples.<br> <strong><em>Results:</em></strong> Insulin level was 7.02 &plusmn; 3.29 in control group, 11.41 &plusmn; 3.84 in the case group. FBS level was 82.75 &plusmn; 7.18 in control group versus 84.03 &plusmn; 5.82 in case group. E2 level was 70.74 &plusmn; 53.03 in control group and 60.21 &plusmn; 40.58 in case group. The insulin resistance level was 1.45 &plusmn; 0.74 in the control group versus 2.37 &plusmn; 0.83 in case group. According to correlation analysis, the insulin variable had a significant positive association with BMI (p < 0.0001, r=.245), although no significant correlation was seen between E2 and BMI (p-value = 0.245, r=.092)<br> <strong><em>Conclusion:</em></strong> Present data showed that E2 levels were not different in PCOS and non-PCOS patients, but insulin levels in PCOS were significantly increased and PCOS women had significant insulin resistance which is dependent on BMI.<br> &nbsp;</div> Polycystic ovary syndrome, Insulin, estradiol, BMI 4058 4066 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2903-1&slc_lang=en&sid=1 Hiva Danesh هیوا دانش hivadanesh@yahoo.com 100319475328460026442 100319475328460026442 No 1. Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran 2. Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran 1. کمیته تحقیقات دانشجویان، دانشگاه علوم پزشکی همدان، همدان، ایران 2. گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران Sahar Mazloomi سحر مظلومی saharmazloomi1001@yahoo.com 100319475328460026443 100319475328460026443 No 1. Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran 2. Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran 1. کمیته تحقیقات دانشجویان، دانشگاه علوم پزشکی همدان، همدان، ایران 2. گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران Zeinab Barartabar زینب برارتبار zeinabbarartabar@gmail.com 100319475328460026444 100319475328460026444 No 1. Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran 2. Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran 1. کمیته تحقیقات دانشجویان، دانشگاه علوم پزشکی همدان، همدان، ایران 2. گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران Narges Alizadeh نرگس علیزاده nargesalizade4230@gmail.com 100319475328460026445 100319475328460026445 No 1. Shariati Hospital, Alborz University of Medical Sciences, Alborz, Iran 2. Hamadan University of Medical Sciences, Hamadan, Iran 1. بیمارستان شریعتی، دانشگاه علوم پزشکی البرز، البرز، ایران 2. دانشگاه علوم پزشکی همدان، همدان، ایران Shamim Pilehvari شمیم پیله وری sh.pilehvar@umsha.ac.ir 100319475328460026446 100319475328460026446 Yes 1. Department of Obstetrics and Gynaecology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran 2. Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran 1. گروه زنان و زایمان، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران 2. مرکز تحقیقات اندومتر و اندومتریوز، دانشگاه علوم پزشکی همدان، همدان، ایران