Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
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8888
13
en
jalali
1399
8
1
gregorian
2020
11
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online
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fulltext
fa
مقایسه سمیت اسانس میخک (Syzygium aromaticum) و ماده اصلی تشکیلدهنده آن (اوژنول) بر روی ردههای سلولی سرطان پستان
خاصیت ضد سرطانی اسانس میخک و اوژنول
Comparing the Cytotoxic Effects of Clove Essential Oil (Syzygium Aromaticum) and its Major Compound (Eugenol) Against Some Human Breast Cancer Cell Lines
داروسازي و فارماکولوژِی
Pharmacology
پژوهشي
Research
<div style="text-align: justify;"><strong><em>Background & Objective:</em></strong> Breast cancer is the most common cancer among women, especially in developed countries. Because of resistance to chemotropic drugs, the development of new green drugs is crucial. Essential oils with a broad range of bioactivities such as antioxidant and anticancer activities are great resources for research and development. In this study, anticancer effects of clove (<em>Syzygium aromaticum</em>) essential oil as the common medicinal plant against some human breast cancer cell lines was investigated.<br>
<strong><em>Materials & Methods:</em></strong> Components of clove essential oil were identified. The anticancer effect of the essential oil and its major ingredient (eugenol) was investigated on four human breast cancer cell lines.<br>
<strong><em>Results:</em></strong> Ninety-two percent of clove essential oil was included by eugenol (65%), <em>trans</em>-caryophyllene (12%), eugenol acetate (10%), caryophyllene oxide (3%), and a-humulene (2%). Both clove essential oil and eugenol showed proper effect (IC<sub>50</sub> µg.mL<sup>-1</sup>) on targeted cell lines, MCF-7 (151.94 and 86.13), MDA-MB-175 (162.92 and 33.25), MDA-MB-231 (180.61 and 69.75), and MDA-MB-468 (211.11 and 53.91).<br>
<strong><em>Conclusions:</em></strong> Regarding the proper anticancer effects of both samples, they could be considered as anticancer agents for further investigation.<br>
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</div>
Syzygium aromaticum, eugenol, anticancer effect
3028
3034
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2124-1&slc_lang=fa&sid=1
Hiva
Alipanah
هیوا
علی پناه
alipanah.hiwa@yahoo.com
100319475328460024808
100319475328460024808
No
Department of Physiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران
Ali
Ghanbariasad
علی
قنبری اسد
alighanbariasad@gmail.com
100319475328460024809
100319475328460024809
No
Department of Medical Biotechnology, Schools of Medicine, Fasa University of Medical Sciences, Fasa, Iran
گروه بیوتکنولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران
Mahmoud
Osanloo
محمود
اوصانلو
osanloo_mahmood@yahoo.com
100319475328460024810
100319475328460024810
Yes
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
مرکز تحقیقات بیماریهای غیر واگیر، دانشگاه علوم پزشکی فسا، فسا، ایران