en ارتباط ویسفاتین با گلوکز خون ، مقاومت به انسولین و شاخص توده بدن در بیماران مبتلا به دیابت نوع 2 / دیابت بیومکانیک Biomechanics پژوهشي Research <div style="text-align: justify;"><a name="_Hlk69161895"><strong><em>Background </em></strong></a><strong><em>&</em></strong><strong><em> Objective: </em></strong>In recent studies visfatin has been introduced as a multifaceted protein that plays a role in pathogenesis of many disorders and disease such as obesity and type 2 diabetes. The aim of this study was to evaluate the association of visfatin with fasting blood glucose, insulin resistance and body mass index in patients with type 2 diabetes <span dir="RTL">/</span> impaired fasting glucose (T2DM, IFG) compared to non-diabetic subjects<span dir="RTL">.</span><br> <strong><em>Material & Methods:</em></strong> This case control study was performed on 160 volunteers. 80 participants were categorized in type 2 diabetic group holding FBG &ge;100 (mg/dl) and 80 participants were categorized in non-diabetic (healthy) group holding FBG 70-100 (mg/dl). Serum visfatin levels were measured using enzyme-linked immune sorbent assay (ELISA) and HOMA-IR equation was used for insulin sensitivity check.<br> <strong><em>Results: </em></strong>The result was presented as mean+ standard deviation and p<0.05 was considered as statistically significant<strong>. </strong>Diabetic group showed a higher level of age in comparison with the non-diabetics. Meanwhile, the means of TG, FBG, BMI, WC, HC and HOMA were also significantly different between the two groups. Visfatin level was not different between diabetics and normal healthy controls. There was a positive correlation between visfatin and BMI in non-diabetics. Also, in diabetics there was a positive correlation between visfatin and BMI, HDL, Hip, insulin and HOMA-IR and a negative correlation between visfatin and FBG level.<br> <strong><em>Conclusion:</em></strong> Our study showed that there was an association between visfatin and BMI but not with type 2 diabetes. Also, there was a significant association between this adipokine and insulin resistance in diabetic and pre-diabetic patients which indicates the pathological role of visfatin in insulin resistance.&nbsp;<br> &nbsp;</div> Type 2 diabetes, visfatin, insulin resistance, body mass index, fasting blood glucose 3984 3992 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2379-2&slc_lang=en&sid=1 helma Karimi حلما کریمی helma.k4455@yahoo.com 100319475328460026410 100319475328460026410 Yes Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Science, Tehran Iran مرکز تحقیقات غدد درون ریز سلولی و مولکولی، پژوهشکده علوم غدد درون ریز، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران Masoumeh Nezhadali معصومه نژادعلی ma_nejadali@yahoo.com 100319475328460026411 100319475328460026411 No Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran گروه زیست شناسی،دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران Maryam Mahdavi مریم مهدوی ma_nejadali@yahoo.com 100319475328460026412 100319475328460026412 No Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran گروه آمار زیستی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران Mino Saatian مینو ساعتیان ma_nejadali@yahoo.com 100319475328460026413 100319475328460026413 No Department of Pathology, Islamic Azad University, Medical Tehran Branch, Tehran, Iran گروه آسیب شناسی ، دانشگاه آزاد اسلامی واحد پزشکی تهران ، تهران ، ایران Leila Saiedi لیلا سعیدی helma.k4455@yahoo.com 100319475328460026414 100319475328460026414 No Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran گروه زیست شناسی،دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران