Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1399
8
1
gregorian
2020
11
1
10
4
online
1
fulltext
fa
تهیهی بازهای شیف دارای ناجورحلقه و بررسی فعالیت ضد باکتریایی و خواص فیزیکو شیمیایی آن-ها
Synthesis of Heterocyclic Schiff Bases and Evaluation of Their Antibacterial Activities and Physicochemical Properties
داروسازي و فارماکولوژِی
Pharmacology
پژوهشي
Research
<div style="text-align: justify;"><strong><em>Background & Objectives:</em></strong> Over the past few decades different Schiff bases have been studied which show that these compounds are prepared by condensation reaction of aldehydes and ketones with different amines. In this research, some heterocyclic Schiff bases were synthesized and their antibacterial activity were evaluated against different bacteria. In continuation of research, physicochemical properties of synthetic Schiff bases were predicted.<span dir="RTL"></span><br>
<strong><em>Materials & Methods:</em></strong> In this research, initially, compounds <strong>3a-3c</strong> and <strong>6</strong> were synthesized through condensation reaction of benzaldehyde derivatives with pyridine-2-amine and thiophen-2-amine derivatives. The structures of the synthetic Schiff bases were confirmed by spectroscopy data such as infrared, mass spectrometric, nuclear magnetic resonance of hydrogen and carbon. Antibacterial activity of all synthesized compounds were evaluated against different bacteria (<em>Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis and </em><em>Klebsiella </em><em>pneumoniae)</em>. Also, physicochemical properties perpetrated heterocyclic Schiff bases checked using Molinspiration calculating server.<br>
<strong><em>Results:</em></strong> Among these synthetic derivatives, compounds <strong>3a</strong> and <strong>3c </strong>are the most effective compounds against Salmonella typhi. Physicochemical analysis indicated that all the synthesized compounds have good oral absorption from intestinal tract.<br>
<strong><em>Conclusion:</em></strong> Among these synthetic heterocyclic Schiff bases, compounds <strong>3a</strong> and <strong>3c</strong> could be considered as antibacterial agents with broad spectrum. Physicochemical properties showed that all the compounds obeyed Lipinski’s rule of five and likely have a good oral absorption.<br>
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Schiff Base, Antibacterial Properties, Heterocyclic, Physic-chemical Properties
2977
2985
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2839-1&slc_lang=fa&sid=1
Khadijeh
Rabiei
خدیجه
ربیعی
kh@yahoo.com
4650639085
100319475328460024860
Yes
Department of Organic Chemistry, Qom University of Technology, Qom, Iran
گروه شیمی آلی، دانشگاه صنعتی قم، قم، ایران