fa مطالعه اثر محافظتی کوآنزیم Q10 بر لقاح داخل آزمایشگاهی و شاخص­های استرس اکسیداتیو در موش سوری تحت تیمار با نانوذرّات نقره جنين شناسي Embryology پژوهشي Research <pre style="text-align: justify;"> <strong><em>Background & Objectives:</em></strong> Coenzyme Q₁₀ has potent antioxidant properties and is involved in the redox cycle as an energy carrier. Silver nanoparticles increase the potential hazards on the reproductive system by producing reactive oxygen species and reduce sperm quality and fertility. The aim of this study was to investigate the effects of silver nanoparticles on in vitro fertilizing potential and oxidative stress indices in mice.</pre> <pre style="text-align: justify;"> <strong><em>Materials & Methods:</em></strong> In this study, 20 adult male mice were divided into 5 control and experimental groups. The control group did not receive any substances. In the experimental groups, silver nanoparticles were fed at doses of 50 and 100 mg/kg. In one group, coenzyme Q₁₀ was given at a dose of 200 mg/kg alone. In the last group, the animals received silver nanoparticles + coenzyme Q₁₀ together. After the treatment period, the mice were euthanized. For testosterone investigation, blood sampling and then for IVF evaluation, sperms from the tail of the epididymis were taken. Testicular tissue was sampled to assess TAC, and MDA and were analyzed by one-way ANOVA and then Tukey test (p<0.05).</pre> <pre style="text-align: justify;"> <strong><em>Results:</em></strong> IVF results showed that the quality of the fetus and its growth stages in the experimental groups were significantly diminished compared to the control group (p<0.05). Also, malondialdehyde level and total antioxidant capacity in experimental groups increased and decreased significantly compared to the control group, respectively.<span dir="RTL"></span></pre> <pre> <strong><em>Conclusions:</em></strong> The present results exhibited that coenzyme Q₁₀ was able to improve the adverse effects of silver nanoparticles on the reproductive system, sperm quality, and fertility.<strong><span dir="RTL"></span></strong></pre> <pre dir="RTL"> &nbsp; </pre> <pre dir="RTL"> &nbsp;</pre> Silver nanoparticles, IVF, Embryologic development, Oxidative stress, Coenzyme Q10 2758 2767 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2520-3&slc_lang=fa&sid=1 Ramin Jahangirfard رامین جهانگیرفرد r.jahangirfard@urmia.ac.ir 5040067321 100319475328460023904 Yes Department of Comparative Anatomy and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran گروه آناتومی و جنین‌شناسی مقایسه‌ای، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران