fa بررسی بیان ژن‌ CD44 در افراد مبتلابه سرطان ریه در استان تهران بيولوژي سلولی-مولكولي Cellular-Molecular Biology پژوهشي Research <div style="text-align: justify;"><strong><em>Background & Objective</em></strong><em>:</em> CD44 is a cellular protein that has been extensively studied for carcinogenicity over the past decade, so the aim of this study is to investigate the expression of CD44 gene in people with lung cancer.<span dir="RTL"></span><br> <strong><em>Materials & Methods:</em></strong> 30 tissue samples were taken from the lung tumor and 30 samples were taken from healthy lung tissues. RNA samples were extracted and used for cDNA synthesis. The Real Time RT-PCR test with the GAPDH internal control gene was used to assess CD44 gene expression.<span dir="RTL"></span><br> <strong><em>Results</em></strong><strong>:</strong> CD44 gene expression in tumor tissues, men, age group over 60 years, smokers and adenoma tumor, respectively 1.2, 1.4, 1.1, 1.9 and 1.1 times higher than healthy samples, women, age group Under 60 years of age, non-smokers had SCC tumors.<br> <strong><em>Conclusion</em></strong>: Inflammation caused by lung cancer increased the production of CD44 inflammatory factor and thus increased its expression. Evaluating the expression of CD44 gene can be used as a marker to predict lung cancer.<br> &nbsp;</div> <br> <span dir="RTL"></span> Lung cancer, CD44, gene expression, Real Time RT-PCR 3074 3084 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2076-6&slc_lang=fa&sid=1 Zahra Ahmadzadeh Chaleshtari زهرا احمدزاده zahraahmadzadeh69@yahoo.com 100319475328460024834 100319475328460024834 No Department of Biology, Science Faculty, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran گروه زیست‌شناسی، دانشکده علوم پایه، واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران noosha Zia-jahromi نوشا ضیاء nooshazia.59@gmail.com 100319475328460024835 100319475328460024835 Yes Department of Biology, Science Faculty, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran گروه زیست‌شناسی، دانشکده علوم پایه، واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران