fa بررسی تأثیر مصرف رزوراترول بر پروفایل متابولیکی سرمی بیماران دیابتی نوع 1 با استفاده از روش طیف‌سنجی تشدید مغناطیسی هسته (1HNMR) بيوشيمي بالینی Biochemistry پژوهشي Research <div style="text-align: justify;"><strong><em>Background & Objective:</em></strong>&nbsp;Diabete<strong>s&nbsp;</strong>mellitus type 1 is an autoimmune disease in which the B-cells of the pancreas are damaged, leading to insulin deficiency and finally hyperglycemia. The purpose of this study was to investigate the effect of resveratrol consumption on cellular metabolic pathways in type 1 diabetic patients using proton nuclear magnetic resonance spectroscopy.&nbsp;<br> <strong><em>Materials & Methods:</em></strong>&nbsp;Thirteen individuals with type 1 diabetes participated in this clinical trial designed as before and after exploratory investigation. All the participants received 500mg capsules of resveratrol twice daily for 60 days. Blood collection was done before resveratrol supplementation, after 30 days, and at the end of 60 days. The data were obtained at three different timings, compared with applying the HNMR spectroscopy. Spectra were processed, and PLS-DA analysis methods were applied to data. Outliers were taken, and the HMDB metabolites databank specified the metabolites and its pathways.&nbsp;<br> <strong><em>Results</em></strong><em>:</em> The main variations identified in this investigation were as follows: short and long-chain fatty acid metabolism, the metabolic pathway of triacylglycerol, 1-propanol, and ethanoic acid, leading to an increase in butyraldehyde and 1-butanol metabolites.<br> <strong><em>Conclusion:</em></strong>&nbsp;The results of this research showed a reduction in palmitic acid biosynthesis. This finding suggests that resveratrol may cause significant changes in adipocyte metabolism by inducing adipogenesis and apoptosis in the adipocyte. It may also play a role in improving the production of insulin, leading to low blood glucose levels.&nbsp;<br> &nbsp;</div> Resveratrol, Type 1 diabetes, Metabolomics, 1H NMR, PLS-DA 2847 2857 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2164-3&slc_lang=fa&sid=1 Seyed Hamidreza Hodaei سید حمید رضا هدایی r.rahimi@bpums.ac.ir 100319475328460024242 100319475328460024242 No Department of Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر، بوشهر، ایران Samad Akbarzadeh صمد اکبرزاده SMD.akbarzade@yahoo.com 100319475328460024243 100319475328460024243 No Department of Biochemistry, The Persian Gulf Infectious & Tropical Medicine Research CenterBushehr University of Medical Sciences, Bushehr, Iran گروه بیوشیمی، مرکز تحقیقات طب گرمسیری و عفونی خلیج‌فارس، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر، بوشهر، ایران Mohammad Arjmand محمد ارجمند rahimehrahimi2023@gmail.com 100319475328460024244 100319475328460024244 No Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran گروه بیوشیمی، انستیتو پاستور ایران، تهران، ایران Ziba Akbari زیبا اکبری mostafadarab68@gmail.com 100319475328460024245 100319475328460024245 No Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran گروه بیوشیمی، انستیتو پاستور ایران، تهران، ایران Najmeh Hajian نجمه حاجیان najmeh32@yahoo.com 100319475328460024246 100319475328460024246 No Department of Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر، بوشهر، ایران azam amini اعظم امینی rahimehrahimi2023@gmail.com 100319475328460024247 100319475328460024247 No Bushehr University of Medical Sciences, Bushehr, Iran دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر، بوشهر، ایران Ali Movahed علی موحد amovahed58@gmail.com 2370314249 100319475328460024248 Yes Department of Biochemistry, The Persian Gulf Infectious & Tropical Medicine Research CenterBushehr University of Medical Sciences, Bushehr, Iran گروه بیوشیمی، مرکز تحقیقات طب گرمسیری و عفونی خلیج‌فارس، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر، بوشهر، ایران