fa تأثیر ده هفته تمرین ورزشی تناوبی با شدت بالا بر سطوح استراحتی برخی عوامل آنژیوژنز و عملکرد ریوی مردان مبتلابه سرطان پروستات فيزيولوژي Physiology پژوهشي Research <span dir="RTL"></span>&nbsp;<strong><em>Background & Objective:</em></strong> Prostate cancer is the most common malignancy and the eighth cause of death in Iran. Angiogenesis is the major cause of metastatic and drug resistance in this cancer. The aim of this study was to investigate the effects of 10 weeks of high intensity periodic exercises on resting levels of some angiogenesis markers and also the pulmonary function of men with prostate cancer.<span dir="RTL"></span><br> <strong><em>Materials & Methoed:</em></strong> 20 male patients with prostate cancer aged 55 to 62 years old were randomly divided into two groups (n = 10) and experimental (n = 10). The experimental group subjected to 10 weeks of periodic exercise with intensity progressed weekly, three sessions for 40 minutes and intensity of 70-75 was set for each session. 48 hours before and after exercise, the serum levels of VEGF, FGF, nitric oxide (NO) and also pulmonary function were measured. Intra and intergroup changes were analyzed using dependent t-test and independent t-test, respectively.<span dir="RTL"></span><br> <strong><em>Results:</em></strong> The results showed that 10 weeks of severe periodic training significantly increased the levels of VEGF (P = 0.001), FGF (P = 0.001) and NO (P = 0.001) in the experimental group compared with the control group. Moreover, considering the results, FVC in patients with periodic exercise has increased significantly (P = 0.002).<span dir="RTL"></span><br> <strong><em>Conclusion:</em></strong> As for results, it can be concluded that 10 weeks of periodic exercise increases the angiogenesis and pulmonary function in patients suffered from prostate cancer.<br> &nbsp;<br> &nbsp; High-intensity interval training, prostate cancer, angiogenesis markers, pulmonary function 1097 1105 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1830-1&slc_lang=fa&sid=1 Fazlollah Fathollahi فضل الله فتح الهی f.fathollahi1363@gmail.com 4199719059 100319475328460029395 No Department ofSport Sciences, Faculty of Humanities, ShahrekordUniversity, Shahrekord, Iran گروه تربیت‌بدنی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران Mohammad Faramarzi محمد فرامرزی sdfghjk@yahoo.com 100319475328460029396 100319475328460029396 Yes Department of Sport Physiology, Faculty of Humanities, Shahrekord University, Shahrekord, Iran گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران Rouhollah Hemmati روح الله همتی sdfghjkl2yahoo.com 100319475328460029397 100319475328460029397 No Department of Biology, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran گروه زیست‌شناسی، دانشکده علوم پایه، دانشگاه شهرکرد، شهرکرد، ایران