fa اثرات ضد‌اکسایشی تمرین شنا و کورکومین در دوره ترک مصرف افراطی الکل در موش‌های صحرایی فيزيولوژي Physiology پژوهشي Research <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">زمینه و هدف</span></span></span></strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">: مصرف بیش‌ازحد الکل می&shy;تواند باعث افزایش رادیکال&shy;های آزاد گردد. هدف از تحقیق حاضر بررسی اثر تمرین شنا و کورکومین در دوره ترک مصرف افراطی الکل بر </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">سوپر اکسید دیسموتاز </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">(SOD)</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">، گلوتاتیون پراکسیداز</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">(GPX)</span></span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">، </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">ظرفیت آنتی‌اکسیدانی تام (</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">TAC</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">)، مالون دی آلدئید (</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">MDA</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) و پروتئین کربونیل (</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">PC</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) موش&shy;های صحرایی بود.</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;"></span></span></span></span><br> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">مواد و روش&shy;ها</span></span></span></strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">: 40</span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> سر موش‌ </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">انتخاب و </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">چهار روز هر هشت ساعت یک‌بار الکل مصرف نمودند، </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">سپس 6 روز مصرف الکل را ترک نموده و در روز هفتم در 5 گروه (1) کنترل (2) کورکومین (3) شنا (4) کورکومین و شنا و (5) شم قرار گرفتند. گروه&shy;های 3 و 4 پنج جلسه در هفته به مدت دو هفته شنا کردند و گروه&shy;های 2 و 4 پنج بار در هفته به مدت دو هفته </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">mg/kg</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">50 کورکومین دریافت نمودند. تجزیه‌وتحلیل یافته&shy;ها با استفاده از آزمون </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">آنالیز واریانس دوطرفه انجام شد (05/0</span></span></span><span style="color:black;"><span style="font-family:arial,sans-serif;"><span style="font-size:10.0pt;">&ge;</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">).</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;"></span></span></span></span><br> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">نتایج:</span></span></span></strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> شنا اثر معنی‌داری برافزایش </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">SOD</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">)</span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">، </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">GPX</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">TAC</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (009/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و کاهش </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">MDA</span></span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">(001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) و </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">PC</span></span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">(001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) دارد، مصرف کورکومین اثر معنی‌داری برافزایش </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">SOD</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">GPX</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و کاهش </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">MDA</span></span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">(001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) و </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">PC</span></span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">(001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) دارد ولی بر </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">TAC</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> اثر معنی‌داری ندارد (34/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">)</span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">همچنین شنا هم‌زمان با مصرف کورکومین دارای اثرات تعاملی برافزایش</span></span></span> <span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">SOD</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">GPX</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (001/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و کاهش </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">PC</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (009/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) است ولی دارای اثرات تعاملی بر </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">TAC</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> (48/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) </span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">MDA</span></span></span></span> <span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">(13/0=</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:8.0pt;">p</span></span></span></span><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) نیست.</span></span></span><br> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">نتیجه&shy;گیری</span></span></span></strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">: احتمالاً بتوان از تمرین شنا هم‌زمان با مصرف کورکومین در دوره ترک مصرف افراطی الکل جهت افزایش عوامل آنتی&shy;اکسیدانی استفاده نمود.</span></span></span><br> &nbsp; <pre> <strong><em>Background & Objective:</em></strong> Alcohol overdose can induce increment in free radicals. The present study aimed to&nbsp; investigate the effect of swimming training and Curcumin in withdrawal period of alcohol overdose on superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), malone dealdeid (MDA) and protein carbonyl (PC) of rats. </pre> <pre> <strong><em>Materials & </em></strong><strong><em>Methods:</em></strong> 40 rats were selected and administered alcohol every 8 hours for 4 days. Then they were subjected to the withdrawal of alcohol for six days and in seventh day divided in 5 groups of 8 rats (1) control (2) Curcumin (3) swimming training (4) Curcumin and swimming training (5) sham. Groups 3 and 4 swam 5 sessions per week for 2 weeks and groups 2 and 4 used Curcumin 5 times per week for 2 weeks peritoneally. For statistical analysis of data two-way ANOVA was used (p&le;0.05).</pre> <strong><em>Results:</em></strong> Swimming training had significant effect on increase of SOD (p=0.001), GPX (p=0.001) and TAC (p=0.009) and reduction of MDA (p=0.001) and PC (p=0.001) of rats. Curcumin had significant effect on increase of SOD (p=0.001) and GPX (p=0.001) and reduction of MDA (p=0.001) and PC (p=0.001) of rats but had no significant effect on TAC (p=0.34) also Curcumin and swimming training had interactive effects on increase of SOD (p=0.001) and GPX (p=0.001) and reduction of PC (p=0.009) of rats but had no interactional effect on TAC (p=0.48) and MDA (p=0.13).<span dir="RTL"></span> <pre> <strong><em>Conclusion:</em></strong> Probably, swimming training and curcumin can be applied simultaneously in withdrawal period of alcohol overdose to increase antioxidant factors.</pre> تمرین شنا, کورکومین, الکل, آنتی‌اکسیدان Swimming training, Curcumin, Antioxidant, Alcohol 901 910 http://jabs.fums.ac.ir/browse.php?a_code=A-10-1701-2&slc_lang=fa&sid=1 Asiye Seyed آسیه سید asiyeseyyed1389@gmail.com 1860340865 100319475328460018955 Yes Islamic Azad University, Larestan, Iran گروه فیزیولوژی ورزشی، واحد لارستان، دانشگاه آزاد اسلامی، لار، ایران Sirous Farsi سیروس فارسی sirous.farsi@gmail.com 2431813673 100319475328460018956 No Islamic Azad University, Larestan, Iran گروه فیزیولوژی ورزشی، واحد لارستان، دانشگاه آزاد اسلامی، لار، ایران Seyed Ali Hosseini سید علی حسینی alihoseini_57@yahoo.com 6449825537 100319475328460018957 No Marvdasht Branch, Islamic Azad University, Marvdasht, Iran گروه فیزیولوژی ورزشی، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران Gholamreza Kaka غلامرضا کاکا gh_kaka@yahoo.com 0042867916 100319475328460018958 No Bagiyatallah University of Medical Sciences, Tehran, Iran گروه علوم تشریح،دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران.