TY - JOUR T1 - Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer TT - بررسی ارتباط واریانت ژنتیکی rs1862513 در ژن رزیستین بااستعداد ابتلا به سرطان سینه JF - JABS JO - JABS VL - 7 IS - 2 UR - http://jabs.fums.ac.ir/article-1-1166-en.html Y1 - 2017 SP - 217 EP - 222 KW - Resistin KW - Breast cancer KW - Promoter KW - Genetic variant N2 - Background & objective: Resistin is a unique hormone secreted from adipocytes. Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic inflammation plays a role in breast cancer, it seems that resistin may present a molecular link between inflammation and breast carcinogenesis. The aim of this study was to investigate the association of rs1862513 promoter resistin gene variant with breast cancer risk. Material & Methods: For the purpose of this case-control study, 150 breast cancer and 150 healthy control blood samples were collected. After DNA extraction, genotype determination was performed by PCR-RFLP method. Statistical analysis was done using logistic regression model. Results: The case and control groups were in Hardy-Weinberg equilibrium. The subjects with GG genotype had increased risk of breast cancer compared to those with CC genotype (OR: 1.9, 95% CI: 1-3.7, P: 0.04). Also, the G allele indicated a positive association with breast cancer susceptibility (OR: 1.4, 95% CI: 1-1.98, P: 0.03). Conclusion: Results of this study showed possible association of resistin rs1862513 gene variant with breast cancer risk in Iranian women. M3 ER -